Retinal Nerve Fiber Layer Optical Texture Signature as a Novel Biomarker for Detection of Glaucoma Progression

Professor Leung, Kai Shun   (Principal Investigator (PI))

Dr Wan Ho Nam Kelvin   (Co-Investigator)

Dr Yu Chak Yan Marco   (Co-Investigator)

Dr Yick Wai Fong Doris   (Co-Investigator)

Dr Kam Ka Wai   (Co-Investigator)

42

2019-01-01

2022-06-30

956010

Retinal Nerve Fiber Layer Optical Texture Signature as a Novel Biomarker for Detection of Glaucoma Progression

Detection, Glaucoma, Nerve, Optical, Retinal, Texture

Vision

Biology and Medicine (M)

14101518

General Research Fund (GRF)

2018

Completed

1 To compare the hazard ratios for development of visual field progression upon detection of progressive decline in retinal nerve fiber layer (RNFL) optical texture signature versus upon detection of progressive RNFL thinning 2 To compare the survival distributions between eyes with progressive RNFL thinning and eyes with progressive decline in RNFL optical texture signature 3 To determine the specificities of Trend-based Progression Analysis (TPA) for detection of progressive decline in RNFL optical texture signature and progressive RNFL thinning 4 To measure rates of change of VF mean deviation between eyes with and without progressive decline in RNFL thickness/optical texture signature 5 To measure age-related rates of change of RNFL thickness/optical texture signature