Optogenetic fMRI Investigation of Brain-wide Spindle Activities
Grant Data
Project Title
Optogenetic fMRI Investigation of Brain-wide Spindle Activities
Principal Investigator
Dr Leong, Tze Lun
(Principal Investigator (PI))
Co-Investigator(s)
Dr Liang Zhifeng
(Co-Investigator)
Dr Lim Lee Wei
(Co-Investigator)
Duration
36
Start Date
2021-10-01
Completion Date
2025-05-26
Amount
1325732
Conference Title
Optogenetic fMRI Investigation of Brain-wide Spindle Activities
Keywords
brain oscillations, functional MRI, neuroimaging, optogenetic, thalamo-cortical system
Discipline
Imaging
Panel
Biology and Medicine (M)
HKU Project Code
17127021
Grant Type
General Research Fund (GRF)
Funding Year
2021
Status
Completed
Objectives
1 Design and implement an advanced optogenetic fMRI methodology that combines optogenetic activation/deactivation of thalamo-cortical excitatory neurons with fMRI with high sensitivity and experimental efficiency in awake (unanesthetized) rats using our 7 Tesla MRI. 2 Identify similarities/differences in optogenetically initiated spindle-like activities in the various sensory thalamic nucleus (i.e., VPM/LGN/MGB) and their respective brain-wide targets. 3 Explore the functional roles of brain-wide spindle-like activities via optogenetics, sensory task-based fMRI, and behavioral experiments.