Cortical excitation and inhibition in targeted memory reactivation during sleep

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Grant Data
Project Title
Cortical excitation and inhibition in targeted memory reactivation during sleep
Principal Investigator
Professor Lai, Sau Wan Cora   (Principal Investigator (PI))
Co-Investigator(s)
Professor Hu Xiaoqing   (Co-Investigator)
Duration
36
Start Date
2022-01-01
Completion Date
2025-12-31
Amount
1169056
Conference Title
Cortical excitation and inhibition in targeted memory reactivation during sleep
Keywords
Calcium imaging, Dendritic spine, In vivo imaging, Sleep, Targeted memory reactivation
Discipline
NeuroscienceBiological Imaging
Panel
Biology and Medicine (M)
HKU Project Code
17108821
Grant Type
General Research Fund (GRF)
Funding Year
2021
Status
Completed
Objectives
1 To examine the effect of TMR during specific sleep stages on fear memory consolidation and dendritic spine plasticity. 2 To investigate cortical excitation and inhibition in TMR during specific sleep stages after fear learning. 3 To elucidate the role of interneurons in TMR after fear learning by pharmacogenetic manipulations.