Discovering Bismuth and Relevant Metallo-agents for Medicinal Applications: From Molecular Mechanism of Action to Translational Research

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Grant Data
Project Title
Discovering Bismuth and Relevant Metallo-agents for Medicinal Applications: From Molecular Mechanism of Action to Translational Research
Principal Investigator
Professor Sun, Hongzhe   (Principal Investigator (PI))
Co-Investigator(s)
Professor Yuen Kwok Yung   (Collaborator)
Professor Hao Quan   (Collaborator)
Dr De Reuse Hilde   (Collaborator)
Duration
60
Start Date
2022-01-01
Amount
7798380
Conference Title
Discovering Bismuth and Relevant Metallo-agents for Medicinal Applications: From Molecular Mechanism of Action to Translational Research
Keywords
Antibacterial and antiviral, Bioinorganic chemistry, Bismuth, Medicinal inorganic chemistry, Metalloproteomics
Discipline
Chemical Sciences
Panel
Physical Sciences (P)
HKU Project Code
SRFS2122-7S04
Grant Type
RGC Senior Research Fellow Scheme
Funding Year
2021
Status
On-going
Objectives
1. To build up an integrative platform for metal-protein interactions at the proteome-wide scale for identification of key metallorpoteins from microbial pathogens. 2. To investigate the role of metals and metalloproteins in the interface of host-pathogen interaction, in particular, the effect of pathogenic (metallo)proteins on the pathogenicity of pathogens. 3. To enhance biological efficacy of bismuth and relevant compounds against bacterial and virus infection in vivo through chemical formulation. 4. To build an inter-disciplinary consortium (such as CAS-HKU Joint Laboratory on metallomics for human health and environment) for fundamental and translational research, and to nurture young generation of talent.