Inhibition of microglial P2X4 receptor attenuates neuroinflammation and enhances photoreceptor survival in retinal degeneration

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Grant Data
Project Title
Inhibition of microglial P2X4 receptor attenuates neuroinflammation and enhances photoreceptor survival in retinal degeneration
Principal Investigator
Dr Ho, Yin Chiu Tracy   (Principal Investigator (PI))
Co-Investigator(s)
Professor FLETCHER Erica   (Co-Investigator)
Dr Shan Samantha Sze Wan   (Co-Investigator)
Dr Lin Bin   (Co-Investigator)
Duration
42
Start Date
2018-09-01
Amount
1156072
Conference Title
Inhibition of microglial P2X4 receptor attenuates neuroinflammation and enhances photoreceptor survival in retinal degeneration
Presentation Title
Keywords
Neuroinflammation, Photoreceptor death, Purinergic signalling, Purines, Retina, Retinal degeneration
Discipline
Others - Medicine, Dentistry and Health
HKU Project Code
05161116
Grant Type
Health and Medical Research Fund - Full Grant
Funding Year
2017
Status
On-going
Objectives
The main objective is to investigate the role of the P2X4 receptor (P2X4-R) in the mechanisms of photoreceptor death during retinal degeneration and thereby identify potential treatment strategies to prevent and slow disease progression.