Tumor Microenvironment and Immune Cells in Biliary Tract Malignancies - Molecular Mechanism and Precision Modelling

Professor Man, Kwan   (Principal Investigator (PI))

Professor Lu Jian   (Co-Investigator)

Dr Limaolan Maolan   (Co-Investigator)

Dr Ng Kevin Tak Pan   (Co-Investigator)

Dr Luo Ruibang   (Co-Investigator)

24

2022-03-01

2898660

Tumor Microenvironment and Immune Cells in Biliary Tract Malignancies - Molecular Mechanism and Precision Modelling

Biliary Tract Malignancies, Immune Cells, Molecular Mechanism, Precision Modelling, Tumor Microenvironment

Cell BiologyCancer

MHP/068/20

Mainland-Hong Kong Joint Funding Scheme (MHKJFS)

2021

On-going

Biliary tract malignancies include cholangiocarcinoma and gallbladder cancer. The clinical outcomes are unfavorable due to the late diagnosis, low rate of curative surgery, resistance to chemo- and radiotherapy. Recently, immunotherapy provides promising results for cancer treatment. However, the improvement of the sensitivity of immunotherapy and precise selection criteria are urgently needed. A combination of small molecule drugs and immunotherapy is likely to increase immune response and reduce adverse events. In current project, we aim to establish: (1) the clinical prognosis model based on leveraging convolutional neural network for the clinical outcome prediction and therapeutic selection; (2) the 3D tumor microenvironment co-culture systems for development novel combinative treatment modalities. The proposed models not only will be critically important for improvement of clinical prognosis, but also have great potentials for commercialization