Molecular mechanisms involved in the suppressive effects of garlic derivatives on cell growth and motility in prostate cancer cells

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Grant Data
Project Title
Molecular mechanisms involved in the suppressive effects of garlic derivatives on cell growth and motility in prostate cancer cells
Principal Investigator
Dr Wang, Xianghong   (Principal Investigator (PI))
Co-Investigator(s)
Dr Jin Dong-Yan   (Co-Investigator)
NULL Wong Yong Chuan   (Co-Investigator)
Duration
24
Start Date
2005-08-01
Completion Date
2007-07-31
Amount
951678
Conference Title
Molecular mechanisms involved in the suppressive effects of garlic derivatives on cell growth and motility in prostate cancer cells
Keywords
prostate cancer garlic
Discipline
Cancer
HKU Project Code
N/A
Grant Type
American Institute for Cancer Research (AICR) - General Award
Funding Year
2005
Status
Completed
Objectives
To study the role of the mitotic checkpoint in SAC and SAMC-induced androgen independent prostate cancer cell death; to investigate if SAC and SAMC have any inhibitory effect on the invasive ability of prostate cancer cells and to determine the molecular mechanisms responsible. Specific Aim 3. To examine if SAC and SAMC can enhance the sensitivity of prostate cancer cells to chemotherapeutic drugs.