Detection of rare and low frequency variants and copy number variation associated with systemic lupus erythematosus in Hong Kong Chinese, especially in paediatric-onset patients
Grant Data
Project Title
Detection of rare and low frequency variants and copy number variation associated with systemic lupus erythematosus in Hong Kong Chinese, especially in paediatric-onset patients
Principal Investigator
Professor Yang, Wanling
(Principal Investigator (PI))
Co-Investigator(s)
Professor Lau Yu Lung
(Co-principal investigator)
Dr Lee Pamela Pui Wah
(Co-principal investigator)
Duration
36
Start Date
2023-01-01
Amount
1212815
Conference Title
Detection of rare and low frequency variants and copy number variation associated with systemic lupus erythematosus in Hong Kong Chinese, especially in paediatric-onset patients
Presentation Title
Keywords
""CNVs"", ""Ethnical difference"", ""complex diseases"", ""autoimmune diseases"", ""genetics""
Discipline
Paediatrics
HKU Project Code
PR-HKU-7
Grant Type
Commissioned Paediatric Research at Hong Kong Children's Hospital
Funding Year
2022
Status
On-going
Objectives
In this study, making use of sampoles from our Hong Kong SLE cohort and available data from collaborators, we will have whole genome sequencing data for 1366 samples of SLE cases and matched controls to detect RVs and SV/CNVs associated with SLE, of which 200 caes will be those with an onsety age younger than 18 years old.