Calycosin ameliorates experimental Sjogren’s syndrome via inhibiting effector T cell response
Grant Data
Project Title
Calycosin ameliorates experimental Sjogren’s syndrome via inhibiting effector T cell response
Principal Investigator
Professor Lin, Xiang
(Principal Investigator (PI))
Co-Investigator(s)
Professor Li Philip Hei
(Co-principal investigator)
Duration
24
Start Date
2023-07-20
Amount
1362000
Conference Title
Calycosin ameliorates experimental Sjogren’s syndrome via inhibiting effector T cell response
Keywords
Sjogren’s syndrome, T follicular helper, Calycosin
Discipline
Others - Medicine, Dentistry and Health
Panel
Biology and Medicine (M)
HKU Project Code
20212601
Grant Type
Health and Medical Research Fund 2021
Funding Year
2022
Status
On-going
Objectives
Sjogren’s syndrome (SS) is a systemic autoimmune disease mainly treated by immunosuppressants with increasing doses. Due to the limited understanding of disease pathogenesis, current management of SS has suffered from a lack of effective treatments. Using our established mouse model of experimental SS (ESS), we identified the critical roles of T cell subsets, including T follicular helper (Tfh) cells in SS pathogenesis. However, currently there is no drug targeting Tfh cells in the clinical management.