The role of TOPBP1 in oriP-dependent Epstein-Barr virus latent DNA replication

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Grant Data
Project Title
The role of TOPBP1 in oriP-dependent Epstein-Barr virus latent DNA replication
Principal Investigator
Professor Jin, Dong-Yan   (Principal Investigator (PI))
Co-Investigator(s)
Dr Ye Ziwei   (Co-principal investigator)
Professor Botelho Michael George   (Co-principal investigator)
Duration
36
Start Date
2023-08-01
Amount
1500000
Conference Title
The role of TOPBP1 in oriP-dependent Epstein-Barr virus latent DNA replication
Keywords
Epstein-Barr virus (EBV), nasopharyngeal carcinoma (NPC), TOPBP1, CRISPR, latency II
Discipline
Others - Medicine, Dentistry and Health
Panel
Humanities & Social Sciences (H)
HKU Project Code
22210972
Grant Type
Health and Medical Research Fund 2021
Funding Year
2022
Status
On-going
Objectives
We have found DNA topoisomerase II binding protein 1 (TOPBP1) as a host dependency factor of EBV infection in nasopharyngeal epithelial (NPE) cells. In this study we will fully characterize the role of TOPBP1 in oriP-dependent EBV latent DNA replication.