A Microrobotic Platform with Swarming Magnetic Microgels for Endovascular Embolization

Professor Shum, Ho Cheung   (Co-Principal Investigator (Co-PI) (for projects led by other university))

60

2022-06-30

500000

A Microrobotic Platform with Swarming Magnetic Microgels for Endovascular Embolization

Microrobotic Platform, Swarming Magnetic Microgels, Endovascular Embolization

Robotics and Automation

R4015-21

Research Impact Fund (RIF) 2021/22

2021

On-going

(1) To study and optimize the pH-responsive self-healing ability of the microgels in thephysiological environment. The in vivo performance of the microgel-based embolization, long-tennstability and biological safety of the magnetic microgels will also be evaluated in live animal models.(2) To understand the stability, magnetic control, collective behaviour, and imaging of the magneticmicrogels in whole blood with physiological flow and with aneurysm models using both experimentand modeling.(3) To study the image-guided magnetic control of the swarming microgels in blood vessel model ofplacenta filled with whole blood under the real-time guidance of fluoroscopy/ultrasound imaging.Catheter-assisted strategy for rapid endovascular delively of the swarming microgels using clinicalcatheters will also be developed.(4) To demonstrate the catheter-assisted delivery of magnetic swanning microgels to aneurysmregions, magnetic control of the swarming microgels and on-demand embolization by the pHresponsive microgels in placenta models and validate of the microrobotic platform(5) To complete a report on the feasibility study of the microgels, microrobotic platform andsurgical procedures for the clinical translation with the industrial partners.(6) To acquire sufficient data and prepare the funding application for the further preclinical andclinical studies of the microrobotic platform for aneurysm treatments.