A novel approach to target cancer stemness using peptidic chimeric antigen receptor (pCAR) macrophages

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Grant Data
Project Title
A novel approach to target cancer stemness using peptidic chimeric antigen receptor (pCAR) macrophages
Principal Investigator
Professor Wong, Carmen Chak Lui   (Co-Principal Investigator (Co-PI) (for projects led by other university))
Co-Investigator(s)
Dr Lee Kin-Wah   (Project coordinator)
Duration
48
Start Date
2023-06-01
Amount
500000
Conference Title
A novel approach to target cancer stemness using peptidic chimeric antigen receptor (pCAR) macrophages
Keywords
Cancer stemness, Cancer Immmunotherapy, CAR macrophages, hepatocellular carcinoma, peptide based
Discipline
Gastroenterology/HepatobiliaryCancer
HKU Project Code
R5008-22
Grant Type
Research Impact Fund (RIF) 2022/23
Funding Year
2022
Status
On-going
Objectives
(1) To identify the peptides that selectively bind to the surface receptors of liver CSCs via massspectrometry analysis.(2) To design and establish a library of liver CSC-specific pCAR-Ms using a one-pot peptidecyclization and cell modification approach.(3) To functionally characterize and optimize pCAR-Ms in cell-based models.(4) To evaluate the efficacy of the designed pCAR-Ms in animal models.