Quantifying attenuation effects caused by dinucleotide biases and codon pair biases for development of safe and scalable live attenuated virus vaccines
Grant Data
Project Title
Quantifying attenuation effects caused by dinucleotide biases and codon pair biases for development of safe and scalable live attenuated virus vaccines
Principal Investigator
Dr Gu, Haogao
(Principal Investigator (PI))
Duration
36
Start Date
2023-06-01
Amount
13130
Conference Title
Quantifying attenuation effects caused by dinucleotide biases and codon pair biases for development of safe and scalable live attenuated virus vaccines
Keywords
Quantifying, attenuation, dinucleotide, codon, biases
Discipline
VirologyBioinformatics, Systems and Synthetifc Biology
Panel
Biology and Medicine (M)
HKU Project Code
PDFS2324-7S03
Grant Type
RGC Postdoctoral Fellowship Scheme 2023/24
Funding Year
2023
Status
On-going
Objectives
Recent experiement results from us suggest synoymous mutations in viral genome (e.g. incread CpG frequency in influenza A virus genome) significantly attenuated viral fitness, however knowledge on the respective effects caused by two genomic compositional biases, i.e. condon pair bias and dinucleotide bias, is currently limited. Distinguishing and quantifying the effects from these two factors can greatly promote understandings on virus-host interaction and faciliate vaccine design.