Development of a colistin / adjuvant antimicrobial regimen that exhibits low toxicity and high efficacy in combating multidrug-resistant bacterial pathogens

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Grant Data
Project Title
Development of a colistin / adjuvant antimicrobial regimen that exhibits low toxicity and high efficacy in combating multidrug-resistant bacterial pathogens
Principal Investigator
Professor Li, Xuechen   (Co-Principal Investigator (Co-PI) (for projects led by other university))
Co-Investigator(s)
Dr Chen Sheng   (Project coordinator)
Duration
48
Start Date
2019-06-30
Amount
1428471
Conference Title
Development of a colistin / adjuvant antimicrobial regimen that exhibits low toxicity and high efficacy in combating multidrug-resistant bacterial pathogens
Keywords
Colistin, Adjuvant, Multi-drug resistance, Efficacy, Toxicity
Discipline
Drug Discovery and DeliveryChemical Sciences
HKU Project Code
R5011-18
Grant Type
Research Impact Fund (RIF) 2018/19
Funding Year
2018
Status
Completed
Objectives
(1) Conduct preclinical studies to develop colistin/adjuvant cocktail therapy(2) Unveil the mechanisms underlying the synergistic antimicrobial effect of colistin and adjuvants,imidazole and CET/DOM