Mechanistic study of the defense systems in marine cyanobacteria against bacteriophage infection

View Statistics Email Alert RSS Feed

Grant Data
Project Title
Mechanistic study of the defense systems in marine cyanobacteria against bacteriophage infection
Principal Investigator
Professor Li, Yongxin Philip   (Co-Principal Investigator (Co-PI) (for projects led by other university))
Co-Investigator(s)
Dr Zeng Qinglu   (Project coordinator)
Duration
36
Start Date
2023-06-30
Amount
420000
Conference Title
Mechanistic study of the defense systems in marine cyanobacteria against bacteriophage infection
Keywords
1) Marine virus 2) Cyanobacteria 3) Virus-host interaction 4) Antiphage defense system 5) Prochlorococcus
Discipline
Environmental Research
HKU Project Code
C6012-22G
Grant Type
Collaborative Research Fund (CRF) - Group Research Project 2022/2023
Funding Year
2022
Status
On-going
Objectives
1. Systematically identify antiphage defense genes in marine cyanobacteria by generating mutantcyanobacterial strains2. Investigate the proteins essential for the interaction of cyanobacterial extracellular vesicleswith cyanophages3. Mine the genomics and multiomics data with machine-learning algorithms to predict candidateantiphage defense genes in cyanobacterial genomes and metagenomes4. Study the mechanisms of antiphage defense systems in cyanobacteria using a combination ofgenetics, molecular biology, and structural biology approaches