The role of exomere, a new family member of extracellular vesicles, in liver cancer
Grant Data
Project Title
The role of exomere, a new family member of extracellular vesicles, in liver cancer
Principal Investigator
Professor Yam, Judy Wai Ping
(Principal Investigator (PI))
Duration
60
Start Date
2024-01-01
Amount
5155380
Conference Title
The role of exomere, a new family member of extracellular vesicles, in liver cancer
Keywords
Hepatocellular carcinoma, Tumor microenvironment, Small extracellular vesicles, Exomere, Metastasis
Discipline
Gastroenterology/HepatobiliaryCancer
Panel
Biology and Medicine (M)
HKU Project Code
RFS2324-7S01
Grant Type
RGC Research Fellow Scheme (RFS) 2023/24
Funding Year
2023
Status
On-going
Objectives
- In this study, we aim to investigate the clinical significance and functions of the newly discovered extracellular nanoparticle (ENP), exomere, in hepatocarcinogenesis. Based on our preliminary data, we hypothesize that EFR3A-enriched exomere contributes to hepatocellular carcinoma (HCC) and has diagnostic implication. Here, we propose1. To delineate the mechanistic basis underlying the biogenesis of exomere2. To functionally characterize the effect of EFR3A-enriched exomere in HCC3. To evaluate the clinical relevance of EFR3A-enriched exomere in HCC- Key issues and problems being addressed- Reasons for undertaking the project- Possible outcomes of the research project