Reverse inflammaging by targeting nuclear PD-L1 in inflammatory macrophages

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Grant Data
Project Title
Reverse inflammaging by targeting nuclear PD-L1 in inflammatory macrophages
Principal Investigator
Professor Sugimura, Ryohichi Rio   (Principal Investigator (PI))
Duration
12
Start Date
2023-10-11
Amount
389000
Conference Title
Reverse inflammaging by targeting nuclear PD-L1 in inflammatory macrophages
Keywords
PD-L1, Macrophage, Single-cell, Inflammaging, Interferon
Discipline
Stem Cell BiologyStem Cell Therapy
Panel
Biology and Medicine (M)
HKU Project Code
HLCA/M-701/23
Grant Type
Healthy Longevity Catalyst Awards (Hong Kong) 2023
Funding Year
2023
Status
On-going
Objectives
Objective 1. Define the molecular mechanisms of nuclear PD-L1 regulating inflammatory program in macrophages.Objective 2: Determine therapeutic targets of nuclear PD-L1 to prevent inflammaging.