Discovery of novel molecular glue molecules by using DNA-encoded chemical libraries (DELs)
Grant Data
Project Title
Discovery of novel molecular glue molecules by using DNA-encoded chemical libraries (DELs)
Principal Investigator
Professor Li, Xiaoyu
(Principal Investigator (PI))
Duration
48
Start Date
2024-01-01
Amount
873692
Conference Title
Discovery of novel molecular glue molecules by using DNA-encoded chemical libraries (DELs)
Keywords
DNA-encoded library, molecule glue, combinatorial chemical library, drug discovery, high throughput screening
Discipline
Chemical SciencesDrug Discovery and Delivery
Panel
Physical Sciences (P)
HKU Project Code
N_HKU702/23
Grant Type
NSFC/RGC Joint Research Scheme 2023/24
Funding Year
2023
Status
On-going
Objectives
1. To develop the synthetic strategies that can prepare molecular-glue-focused DNA-encoded libraries (MG-DELs) with high chemical diversities;2. To develop two selection methods that can select the MG-DELs against various proteins and protein complexes for molecular glue discovery;3. To prepare chemically diverse macrocycle and IMiD-MG-DELs and select these libraries against challenging protein targets to identify novel MGs;4. To validate and characterize the biological activities, potency, target specificities, biological activities, and the underlying mechanisms of the identified MGs;5. To summarize the results and identify future research opportunities for more indepth studies in drug discovery.