The investigation of biodegradable zinc-lithium-magnesium alloy as a novel implant to promote osteogenesis through the stimulation of the bone-brain axis
Grant Data
Project Title
The investigation of biodegradable zinc-lithium-magnesium alloy as a novel implant to promote osteogenesis through the
stimulation of the bone-brain axis
Principal Investigator
Professor Qiao, Wei Will
(Principal Investigator (PI))
Co-Investigator(s)
Professor Yeung Kelvin Wai Kwok
(Co-Investigator)
Duration
48
Start Date
2024-01-01
Amount
1212135
Conference Title
The investigation of biodegradable zinc-lithium-magnesium alloy as a novel implant to promote osteogenesis through the
stimulation of the bone-brain axis
Keywords
Biodegradable alloy, Zinc-lithium-magnesium, fracture healing, implant, bone-brain axis
Discipline
BiomaterialsBiomedical Engineering
Panel
Biology and Medicine (M)
HKU Project Code
N_HKU721/23
Grant Type
NSFC/RGC Joint Research Scheme 2023/24
Funding Year
2023
Status
On-going
Objectives
1. To fabricate zinc-lithium-magnesium (Zn-Li-Mg)-based alloy and characterize the physiochemical properties of the materials, including the microstructure, mechanical properties, corrosion behaviors, and degradation rates (by the mainland team);2. To evaluate the biocompatibility of the Zn-Li-Mg alloys and test their effects on the innate immune response and the sensory neural activation using our biomaterial-macrophage-neuron coculture system (by the Hong Kong team).3. To investigate the biological performance of the Zn-Li-Mg alloys as an internal fixation for long bone fracture and the essential role of the bone-brain axis in mediating the therapeutic effects of Zn-Li-Mg implants on bone healing (by both teams).