Clinical Translational Study on The Treatment of Malignant Tumors with Novel Tumor Killer Cell CAR-ITNK
Grant Data
Project Title
Clinical Translational Study on The Treatment of Malignant Tumors with Novel Tumor Killer Cell CAR-ITNK
Principal Investigator
Professor Liu, Pengtao
(Principal Investigator (PI))
Duration
36
Start Date
2022-07-01
Amount
5958488
Conference Title
Clinical Translational Study on The Treatment of Malignant Tumors with Novel Tumor Killer Cell CAR-ITNK
Keywords
Clinical Translational Study, Treatment of Malignant Tumors, Novel Tumor Killer Cell CAR-ITNK
Discipline
Biomedical Engineering
HKU Project Code
MHP/079/20
Grant Type
Mainland-Hong Kong Joint Funding Scheme (MHKJFS)
Funding Year
2022
Status
On-going
Objectives
This project aims to generate the new type of human cytotoxic immune cells, ITNKs and CAR-ITNKs derived from human T cells and stem cells, to characterize them by performing in vitro assays and validating in preclinical models, and to explore T cell-derived CAR-ITNKs for the treatment of malignant tumors. The proposed preclinical and clinical research has four parts: 1. Development of low immunogenic human EPSCs for producing universal and ""off-the-shelf"" immune cells; 2. Generation of ITNKs and CAR-ITNKs from the genetically engineered human EPSCs; 3. Preclinical assessment CAR-ITNKs derived from T cells and from the engineered human EPSCs; 4. Clinical investigation with CAR-ITNKs derived from T cells, focusing on DLBCL therapy