Investigation on the role of prostanoids in obese mice upon coronavirus infection
Grant Data
Project Title
Investigation on the role of prostanoids in obese mice upon coronavirus infection
Principal Investigator
Professor Chu, Hin
(Principal Investigator (PI))
Co-Investigator(s)
Professor Chan Jasper Fuk Woo
(Co-Investigator)
Duration
36
Start Date
2024-07-01
Amount
1494560
Conference Title
Investigation on the role of prostanoids in obese mice upon coronavirus infection
Keywords
coronavirus, SARS-CoV-2 , influenza virus, H1N, diet-induced obese mice
Discipline
Microbiology
HKU Project Code
23220522
Grant Type
Health and Medical Research Fund 2022
Funding Year
2022
Status
On-going
Objectives
COVID-19 is one the worst pandemics in human history. As SARS-CoV-2 Omicron is becoming endemic in the human population, it will continue to circulate in humans and causing new infections annually. People with obesity-related conditions are at higher risk of SARS-CoV-2 infection, associated with delayed SARS-CoV-2 clearance, and are more prone to severe COVID-19 but the underlying mechanism remain incompletely understood. Our study aims to investigate the mechanism of the elevated pathogenicity of SARS-CoV-2 in the obese population and explore novel intervention target for better management of the disease in this population.