The roles of AMP-activating protein kinase at the intersection of Enterovirus A71 (EV-A71) replication and lipid metabolism

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Grant Data
Project Title
The roles of AMP-activating protein kinase at the intersection of Enterovirus A71 (EV-A71) replication and lipid metabolism
Principal Investigator
Dr Ye, Ziwei   (Principal Investigator (PI))
Co-Investigator(s)
Dr Xue Yaqian   (Co-Investigator)
Professor Yuan Shuofeng   (Co-Investigator)
Duration
36
Start Date
2024-07-01
Amount
1499984
Conference Title
The roles of AMP-activating protein kinase at the intersection of Enterovirus A71 (EV-A71) replication and lipid metabolism
Keywords
AMP-activated protein, Enterovirus A71, hand, foot and mouth, lipid metabolism, enteroviral replication
Discipline
Others - Medicine, Dentistry and Health
HKU Project Code
23220602
Grant Type
Health and Medical Research Fund 2022
Funding Year
2022
Status
On-going
Objectives
We have observed an inhibition of EV-A71 replication with administration of activators of AMPK, which is critically involved in the regulation of lipogenesis and fatty acid synthesis. In this study we will delineate the mechanism by which AMPK activation suppresses EV-A71 replication.