Characterizing a monoclonal antibody toolkit for pan-hepatitis E virus diagnostics and therapeutics

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Grant Data
Project Title
Characterizing a monoclonal antibody toolkit for pan-hepatitis E virus diagnostics and therapeutics
Principal Investigator
Professor Sridhar, Siddharth   (Principal Investigator (PI))
Co-Investigator(s)
Professor Kok Kin Hang   (Co-Investigator)
Professor Chan Jasper Fuk Woo   (Co-Investigator)
Duration
36
Start Date
2024-09-01
Amount
1386020
Conference Title
Characterizing a monoclonal antibody toolkit for pan-hepatitis E virus diagnostics and therapeutics
Keywords
Hepatitis E, Monoclonal antibodies, Antigen detection kit , herapeutics, Chronic hepatitis E
Discipline
Microbiology
HKU Project Code
23220722
Grant Type
Health and Medical Research Fund 2022
Funding Year
2022
Status
On-going
Objectives
Hepatitis E virus (HEV) is an important cause of hepatitis. Human-infecting HEV variants were considered to belong exclusively to species A (HEV-A). We discovered that HEV species C (HEV-C; rat hepatitis E) also causes human infection. Both cause chronic infections in immunocompromised persons. We will characterize monoclonal antibodies (mAbs) against both variants and deploy mAbs for a) a pan-HEV antigen immunoassay for differentiating HEV-A and HEV-C in patient sera and b) mAb cocktails for treatment of chronic hepatitis E.