Precision Development and Mechanism Decipherment of Anti-CRPC Nanobody Drugs targeting CEACAM5 with Multimodal Imaging Technology
Grant Data
Project Title
Precision Development and Mechanism Decipherment of Anti-CRPC Nanobody Drugs targeting CEACAM5 with Multimodal Imaging Technology
Principal Investigator
Professor Jiang, Haibo
(Principal Investigator (PI))
Duration
24
Start Date
2024-04-01
Amount
1640935
Conference Title
Precision Development and Mechanism Decipherment of Anti-CRPC Nanobody Drugs targeting CEACAM5 with Multimodal Imaging Technology
Keywords
Anti-CRPC, Nanobody Drugs, CEACAM5, Multimodal Imaging Technology
Discipline
Chemical Sciences
HKU Project Code
MHP/129/22
Grant Type
Mainland-Hong Kong Joint Funding Scheme (MHKJFS)
Funding Year
2023
Status
On-going
Objectives
Prostate cancer is one of the most common male malignancies with a poor prognosis.This project aims to develop nanobody-based drugs for the targeted therapy targeting the‘marker’ protein of castration-resistance prostate cancer (CRPC), CEACAM5. Bydeveloping an artificial intelligence-powered multimodal imaging platform combiningoptical, electron, and ion microscopy, this project will directly visualize nanobodymolecules at the multi-scale (tissue-cell-subcellular), promoting the development ofnanobody-based drugs for prostate cancer and improving the efficiency of the drugdiscovery process of antibody-based therapeutics. The implementation of this project isexpected to significantly improve the therapeutic strategies for prostate cancer andfundamentally improve the survival and prognosis of patients.