Understanding the pattern, determinants, and impact of vaccination on SARS-CoV-2 household transmission
Grant Data
Project Title
Understanding the pattern, determinants, and impact of vaccination on SARS-CoV-2 household transmission
Principal Investigator
Dr Tsang, Ngai Yung Nicole
(Principal Investigator (PI))
Duration
36
Start Date
2024-05-01
Amount
1260270
Conference Title
Understanding the pattern, determinants, and impact of vaccination on SARS-CoV-2 household transmission
Keywords
pattern, determinants, impact of vaccination, SARS-CoV-2, household transmission
Discipline
EpidemiologyPopulation Health
Panel
Biology and Medicine (M)
HKU Project Code
PDFS2425-7S06
Grant Type
RGC Postdoctoral Fellowship Scheme 2024/25
Funding Year
2024
Status
On-going
Objectives
To examine the risk of SARS-CoV-2 transmission to household contacts, when one of the family members is having a RAT-proven infection To examine the comparative prevalence of household-acquired and community-acquired SARS-CoV-2 infection, during different periods of omicron variants predominance in Hong Kong To investigate the determinants of secondary transmission in household settings, including demographical factors, chronic comorbidity, history of previous SARS-CoV-2 infection, clinical illness symptomatology and severity, environmental issues such as household size and composition, flat size, familial role of index case and contact pair To study the comparative clinical symptomatology, including symptom pattern, duration and severity; and the comparative viral shedding pattern of index and secondary cases in the household settingTo estimate the reproductive number (Rt) for SARS-CoV-2 infection in the household setting in relation to directionality of transmission by their familial roles To assess the impact of COVID-19 vaccination on household transmission of the infection, by examining its impact on the infectiousness of index case, in terms of number of secondary cases caused, and the duration and amount of viral shedding; and by examining its impact on the susceptibility of household contacts, in terms of their risk of infection under the standardised exposure of an infected co-inhabiting family member To compare the differential impact of COVID-19 vaccination on the viral shedding pattern of SARS-CoV-2 infection of different vaccine candidates (CoronaVac and BNT162b2) and vaccine doses (full vaccination and booster vaccination)