Effects of adenosine receptors blockade in reshaping tumor immune microenvironment in hepatocellular carcinoma
Grant Data
Project Title
Effects of adenosine receptors blockade in reshaping tumor immune microenvironment in hepatocellular carcinoma
Principal Investigator
Dr Cheu, Wing Sum
(Principal Investigator (PI))
Duration
36
Start Date
2024-07-01
Amount
1260270
Conference Title
Effects of adenosine receptors blockade in reshaping tumor immune microenvironment in hepatocellular carcinoma
Keywords
Effects, adenosine receptors blockade, reshaping, tumor immune microenvironment, hepatocellular carcinoma
Discipline
Cancer
Panel
Biology and Medicine (M)
HKU Project Code
PDFS2425-7S08
Grant Type
RGC Postdoctoral Fellowship Scheme 2024/25
Funding Year
2024
Status
On-going
Objectives
To delineate the role of different adenosine receptors in mediating the effects of adenosine on the status and functions of immune cells To investigate the efficacy of adenosine receptors blockade as single treatment and its effects on tumor immune microenvironment in HCC To explore the therapeutic potential of the combination treatment of adenosine receptors blockade and ICIs or novel therapeutic targets To establish an adenosine pathway signature to predict patients’ responsiveness to adenosine receptors blockade