The Therapeutic Potential of Immunomodulatory Compounds from Astragali Radix on Primary Sjogren’s Syndrome
Grant Data
Project Title
The Therapeutic Potential of Immunomodulatory Compounds from Astragali Radix on Primary Sjogren’s Syndrome
Principal Investigator
Professor Lin, Xiang
(Principal Investigator (PI))
Duration
24
Start Date
2024-04-15
Amount
1659450
Conference Title
The Therapeutic Potential of Immunomodulatory Compounds from Astragali Radix on Primary Sjogren’s Syndrome
Keywords
Therapeutic Potential, Immunomodulatory, Compounds, Astragali Radix, Primary Sjogren’s Syndrome
Discipline
Chinese Medicine (clinical)
HKU Project Code
MHP/104/22
Grant Type
Mainland-Hong Kong Joint Funding Scheme (MHKJFS)
Funding Year
2023
Status
On-going
Objectives
Primary Sjogren’s syndrome (pSS) is a common systemic autoimmune disease inChina. Currently there is no specific treatment strategy. Recent studies have suggestedbeneficial effects of Chinese medicines in treating patients with autoimmune diseasesincluding pSS. We found that Astragalus is the most frequently used in the clinicalpractice. Recently, we have established a novel mouse model of experimental Sjogren’s syndrome (ESS), which highly capitulated human pSS. Together with the humanizedmouse model and corneal organoid from our pilot studies, we collaborated with PekingUniversity Third Hospital, Jilin University, Peking University of Chinese Medicine andLunan Pharmaceutical Group Corporation, to explore the therapeutic potential andimmunomodulatory mechanisms of effective flavonoid compound(s) of Astragalus. Theexpected finding will develop new drugs in forms oral medicine and eye drops for thetreatment of pSS. Currently, we have filed Chinese patent of calycosin for the noveltherapeutic approach in treating pSS.