Development of High-resolution JD Scaffolds with Biomimetic Triply Periodic Minimal Surface Structure for Bone Tissue Repair

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Grant Data
Project Title
Development of High-resolution JD Scaffolds with Biomimetic Triply Periodic Minimal Surface Structure for Bone Tissue Repair
Principal Investigator
Professor Yeung, Kelvin Wai Kwok   (Co-Principal Investigator (Co-PI) (for projects led by other university))
Co-Investigator(s)
Dr ZHAO Xin   (Project coordinator)
Duration
36
Start Date
2022-04-15
Amount
1000000
Conference Title
Development of High-resolution JD Scaffolds with Biomimetic Triply Periodic Minimal Surface Structure for Bone Tissue Repair
Keywords
""1) Hyperboloidal structure"", ""2) 3D printing"", ""3) Osteogenesis"", ""4) Angiogenesis"", ""5) Stem cells""
Discipline
MaterialsProduction and Manufacturing
Panel
Engineering (E)
HKU Project Code
C5044-21G
Grant Type
Collaborative Research Fund (CRF) - Group Research Project 2021/2022
Funding Year
2022
Status
On-going
Objectives
1. To engineer 3D Triply Periodic Minimal Surface (TPMS) scaffolds with designated Gaussian curvatures (-2 to -6) corresponding to natural trabecular bone by high-resolution digital light processing printing. 2. To study the effect of Gaussian curvature on the osteogenic differentiation capability using mesenchymal stem cells and angiogenic capability using endothelial cells and enlighten the underlying molecular mechanism. 3. To incorporate various metal ions (e.g., Zn2+, Cu2+, Mg2+ or Sr2+) into the 3D TPMS scaffolds that aims at reinforcing the osteogenic effect of the Gaussian curvature and investigate the underlying mechanism of enhanced osteogenesis. 4. To modify the TPMS scaffolds with selenocystamine/copper/iron-dopamine coating that facilitates the generation of bioactive gas nitric oxide on Gaussian curvature and investigate the corresponding underlying mechanism of angiogenesis.