Effects of uptake of apoptotic and necrotic cells by dendritic cells (DC) on anti-nuclear antibody production in normal and in lupus prone mouse models
Grant Data
Project Title
Effects of uptake of apoptotic and necrotic cells by dendritic cells (DC) on anti-nuclear antibody production in normal and in lupus prone mouse models
Principal Investigator
Dr Huang, Fang-Ping
(Principal Investigator (PI))
Co-Investigator(s)
Dr Wu Adrian Young Yuen
(Co-Investigator)
Duration
6
Start Date
2001-11-01
Amount
98060
Conference Title
Effects of uptake of apoptotic and necrotic cells by dendritic cells (DC) on anti-nuclear antibody production in normal and in lupus prone mouse models
Presentation Title
Keywords
null
Discipline
N/A
HKU Project Code
N/A
Grant Type
Low Budget High Impact Programme
Funding Year
2001
Status
Completed
Objectives
To test the hypothesis that uptake of dying cells by DC may trigger anti-nuclear auto-antibody (ANA) responses in normal and autoimmune mouse models; to compare the effects of cell death by apoptosis and by necrosis on the induction of ANA responses; to determine the effect of apoptotic cell uptake load on DC immunogenicity in the induction of autoantibody responses; to determine whether uptake of necrotic or apoptotic dying cells by DC may accelerate or down-regulate respectively autoimmune responses in the lupus prone mice.