Investigating the role of Epac in the differentiation of mouse and human embryonic stem cells into insulin-producing cells
Grant Data
Project Title
Investigating the role of Epac in the differentiation of mouse and human embryonic stem cells into insulin-producing cells
Principal Investigator
Dr Lam, Amy Ka Man
(Principal Investigator (PI))
Duration
18
Start Date
2006-09-01
Completion Date
2008-02-29
Amount
65000
Conference Title
Investigating the role of Epac in the differentiation of mouse and human embryonic stem cells into insulin-producing cells
Keywords
Embryonic stem cells, Epac, Insulin-producing cells
Discipline
Diabetes/Metabolism
HKU Project Code
200607176123
Grant Type
Research Centre of Heart, Brain, Hormone and Healthy Aging - General Award
Funding Year
2007
Status
Completed
Objectives
To determine the role of Epac on the expression of beta-cell specific markers in the differentiation of mouse and human embryonic stem cells into pancreatic beta-cells; to determine the effect of Epac knockout in the differentiation of mouse embryonic stem cells to pancreatic beta cells; to determine the survival and in vivo function of Epac transduced or Epac analogue treated hESC-derived insulin-producing cells.