HKU Scholars Hub: Project

Vascular dysfunction in obesity and diabetes: from risk prediction to therapeutic intervention

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Grant Data

Project Title

Vascular dysfunction in obesity and diabetes: from risk prediction to therapeutic intervention

Principal Investigator

Professor Xu, Aimin (Principal Investigator (PI))

Co-Investigator(s)

Professor Wong Kam Bo (Co-Investigator)

Professor Huang Yu (Co-Investigator)

Professor Mak Tak (Collaborator)

Professor Wang Yu (Co-Investigator)

Professor Tse Hung Fat (Co-Investigator)

Emeritus Professor Lam Karen Siu Ling (Co-Investigator)

Professor Vanhoutte Paul Michel Georges Remi (Co-Investigator)

Professor Chan Lawrence (Collaborator)

Duration

Start Date

2008-06-20

Amount

5500000

Conference Title

Vascular dysfunction in obesity and diabetes: from risk prediction to therapeutic intervention

Presentation Title

Keywords

adipokines, diabetes, endothelium, obesity, vasodilation

Discipline

Cardiovascular Research,Diabetes/Metabolism

HKU Project Code

HKU 2/07C

Grant Type

Collaborative Research Fund (CRF) - Group Research Project

Funding Year

2007

Status

Completed

All Publications

Title	Author(s)	Issue Date
Small lipid-binding proteins in regulating endothelial and vascular functions: Focusing on adipocyte fatty acid binding protein and lipocalin-2 Journal:British Journal of Pharmacology	Wang, Y	2012
SIRT1 promotes proliferation and prevents senescence through targeting LKB1 in primary porcine aortic endothelial cells Journal:Circulation Research	Zu, Y Liu, L Lee, MYK Xu, C Liang, Y Man, RY Vanhoutte, PM Wang, Y	2010
Serum adipocyte-fatty acid binding protein level is elevated in severe OSA and correlates with insulin resistance Journal:European Respiratory Journal	Lam, DCL Xu, A Lam, KSL Lam, B Lam, JCM Lui, MMS Ip, MSM	2009
Selective inactivation of c-Jun NH 2-terminal kinase in adipose tissue protects against diet-induced obesity and improves insulin sensitivity in both liver and skeletal muscle in mice Journal:Diabetes	Zhang, X Xu, A Chung, SK Cresser, JHB Sweeney, G Wong, RLC Lin, A Lam, KSL	2011
Lipocalin-2 deficiency attenuates insulin resistance associated with aging and obesity Journal:Diabetes	Law, IKM Xu, A Lam, KSL Berger, T Mak, TW Vanhoutte, PM Liu, JTC Sweeney, G Zhou, M Yang, B Wang, Y	2010
Cross-talk between adipose tissue and vasculature: Role of adiponectin Proceeding/Conference:Acta Physiologica	Li, FYL Cheng, KKY Lam, KSL Vanhoutte, PM Xu, A	2011
Chronic Hepatitis C Is Associated With Peripheral Rather Than Hepatic Insulin Resistance Journal:Gastroenterology	Milner, K van der Poorten, D Trenell, M Jenkins, AB Xu, A Smythe, G Dore, GJ Zekry, A Weltman, M Fragomeli, V George, J Chisholm, DJ	2010
Chronic administration of BMS309403 improves endothelial function in apolipoprotein E-deficient mice and in cultured human endothelial cells Journal:British Journal of Pharmacology	Lee, MYK Li, H Xiao, Y Zhou, Z Xu, A Vanhoutte, PM	2011
Bone morphogenic protein-4 impairs endothelial function through oxidative stress-dependent cyclooxygenase-2 upregulation: Implications on hypertension Journal:Circulation Research	Wong, WT Tian, XY Chen, Y Leung, FP Liu, L Lee, HK Ng, CF Xu, A Yao, X Vanhoutte, PM Tipoe, GL Huang, Y	2010
Berberine prevents hyperglycemia-induced endothelial injury and enhances vasodilatation via adenosine monophosphate-activated protein kinase and endothelial nitric oxide synthase Journal:Cardiovascular Research	Wang, Y Huang, Y Lam, KSL Li, Y Wong, WT Ye, H Lau, CW Vanhoutte, PM Xu, A	2009