Protective effect of thrombopoietin on iron-induced cardiomyopathy

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Grant Data
Project Title
Protective effect of thrombopoietin on iron-induced cardiomyopathy
Principal Investigator
Dr Yang, Mo   (Principal Investigator (PI))
Duration
24
Start Date
2007-07-01
Completion Date
2009-06-30
Amount
190000
Conference Title
Protective effect of thrombopoietin on iron-induced cardiomyopathy
Keywords
cardiomyopathy, Iron, thalassaemia, thrombopoietin
Discipline
Blood/HematologyPaediatrics
HKU Project Code
N/A
Grant Type
Children's Thalassaemia Foundation - General Awards
Funding Year
2007
Status
Completed
Objectives
To investigate the pro-apoptotic effect of iron overload in cardiomyocytes and this effect may be mediated by caspase dependent pathway; to confirm the hypothesis that TPO has a protective effect on iron-induced apoptosis in cardiomyocytes via the activation of Akt signaling pathway.