Chemical synthesis and biological characterizations of antagonists of a novel calcium signaling enzyme - CD38
Grant Data
Project Title
Chemical synthesis and biological characterizations of antagonists of a novel calcium signaling enzyme - CD38
Principal Investigator
Professor Lee, Hon Cheung
(Principal Investigator (PI))
Co-Investigator(s)
Dr Hao Quan
(Co-Investigator)
Professor Zhang Le He
(Co-principal investigator)
Duration
36
Start Date
2009-01-01
Amount
712000
Conference Title
Chemical synthesis and biological characterizations of antagonists of a novel calcium signaling enzyme - CD38
Presentation Title
Keywords
antagonists, enzyme-CD38, novel calcium
Discipline
Physiology,Structural Biology
HKU Project Code
N_HKU 722/08
Grant Type
NSFC/RGC Joint Research Scheme
Funding Year
2008
Status
Completed
All Publications
| Title | Author(s) | Issue Date | |
|---|---|---|---|
Structural studies of intermediates along the cyclization pathway of aplysia ADP-ribosyl cyclase Journal:Journal of Molecular Biology | 2012 | ||
Dynamic conformations of the CD38-mediated NAD cyclization captured in a single crystal Journal:Journal of Molecular Biology | 2011 | ||
Design, synthesis and biological characterization of novel inhibitors of CD38 Journal:Organic and Biomolecular Chemistry | 2011 | ||
Cytosolic CD38 protein forms intact disulfides and is active in elevating intracellular cyclic ADP-ribose Journal:Journal of Biological Chemistry | 2011 | ||
Catalysis-based inhibitors of the calcium signaling function of CD38 Journal:Biochemistry | 2012 |