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Conference Paper: CagA-positive strains increase the risk of gastric cancer in Hong Kong with moderate prevalence of Helicobacter pylori infection and gastric cancer mortality

TitleCagA-positive strains increase the risk of gastric cancer in Hong Kong with moderate prevalence of Helicobacter pylori infection and gastric cancer mortality
Authors
Wong, BCYChu, KMLam, SKKwok, ELai, KCHu, WHCChing, CKCovacci, A
Issue Date1998
PublisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/gastro
Citation
The 1998 Digestive Disease Week (DDW) and the 99th Annual Meeting of the American Gastroenterological Association, New Orleans, LA., 17-20 May 1998. In Gastroenterology, 1998, v. 114 n. suppl. 1, p. A705, abstract no. G2914 How to Cite?
DOI: http://dx.doi.org/10.1016/S0016-5085(98)82892-8
AbstractBACKGROUND: In areas with high prevalence of Helicobacter pylori (Hp) infection and high gastric cancer mortality such as China and Japan, Hp status is not a good marker for increased risk of gastric cancer. The increased risk associated with CagA+ Hp strains are controversial in these areas as well. Hong Kong has a moderate to high prevalence of Hp infection and a gastric cancer mortality of 7.9/105 population. We examine the relationship between Hp, particularly CagA+ strains, and gastric cancer in Hong Kong adults. METHODS: Sera from 52 patients (29 male and 23 females, mean age 59.8 yrs) with non-cardiac type of gastric cancer and 52 age and sex matched asymptomatic controls were examined for anti-Hp antibody by using the commercial ELISA kit (Bio-rad, USA). CagA status was determined by an anti-CagA antibody assay using a purified recombinant CagA fusion protein as antigen using the method described(Am J Gastroenterol 1996:91:949). Results: Hp infection was found in 42 (80.8%) and 35 (67.3%) of gastric cancer patients and controls respectively. Hp infection is associated with a moderate increased risk of gastric cancer (odds ratio 2.04, 95% C.I. 0.83 - 5.02, p=0.089). Among the Hp carriers, 36 (85.7%) and 14 (40%) were cagA+ in the gastric cancer patients and controls respectively. CagA status is associated with a significant increased risk of gastric cancer (O.R. 9.0, 95% C.I. 3.0 - 26.9 …
DescriptionThis journal suppl. entitled: The American Gastroenterological Association and Digestive Disease Week
Persistent Identifierhttp://hdl.handle.net/10722/101494
ISSN
0016-5085
2023 Impact Factor: 25.7
2023 SCImago Journal Rankings: 7.362

 

DC FieldValueLanguage
dc.contributor.authorWong, BCY-
dc.contributor.authorChu, KM-
dc.contributor.authorLam, SK-
dc.contributor.authorKwok, E-
dc.contributor.authorLai, KC-
dc.contributor.authorHu, WHC-
dc.contributor.authorChing, CK-
dc.contributor.authorCovacci, A-
dc.date.accessioned2010-09-25T19:51:57Z-
dc.date.available2010-09-25T19:51:57Z-
dc.date.issued1998-
dc.identifier.citationThe 1998 Digestive Disease Week (DDW) and the 99th Annual Meeting of the American Gastroenterological Association, New Orleans, LA., 17-20 May 1998. In Gastroenterology, 1998, v. 114 n. suppl. 1, p. A705, abstract no. G2914-
dc.identifier.issn0016-5085-
dc.identifier.urihttp://hdl.handle.net/10722/101494-
dc.descriptionThis journal suppl. entitled: The American Gastroenterological Association and Digestive Disease Week-
dc.description.abstractBACKGROUND: In areas with high prevalence of Helicobacter pylori (Hp) infection and high gastric cancer mortality such as China and Japan, Hp status is not a good marker for increased risk of gastric cancer. The increased risk associated with CagA+ Hp strains are controversial in these areas as well. Hong Kong has a moderate to high prevalence of Hp infection and a gastric cancer mortality of 7.9/105 population. We examine the relationship between Hp, particularly CagA+ strains, and gastric cancer in Hong Kong adults. METHODS: Sera from 52 patients (29 male and 23 females, mean age 59.8 yrs) with non-cardiac type of gastric cancer and 52 age and sex matched asymptomatic controls were examined for anti-Hp antibody by using the commercial ELISA kit (Bio-rad, USA). CagA status was determined by an anti-CagA antibody assay using a purified recombinant CagA fusion protein as antigen using the method described(Am J Gastroenterol 1996:91:949). Results: Hp infection was found in 42 (80.8%) and 35 (67.3%) of gastric cancer patients and controls respectively. Hp infection is associated with a moderate increased risk of gastric cancer (odds ratio 2.04, 95% C.I. 0.83 - 5.02, p=0.089). Among the Hp carriers, 36 (85.7%) and 14 (40%) were cagA+ in the gastric cancer patients and controls respectively. CagA status is associated with a significant increased risk of gastric cancer (O.R. 9.0, 95% C.I. 3.0 - 26.9 …-
dc.languageeng-
dc.publisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/gastro-
dc.relation.ispartofGastroenterology-
dc.rightsPosting accepted manuscript (postprint): © 1998. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/-
dc.titleCagA-positive strains increase the risk of gastric cancer in Hong Kong with moderate prevalence of Helicobacter pylori infection and gastric cancer mortality-
dc.typeConference_Paper-
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0016-5085&volume=114&issue=4&spage=A705&epage=&date=1998&atitle=CagA-positive+strains+increase+the+risk+of+gastric+cancer+in+Hong+Kong+with+moderate+prevalence+of+Helicobacter+pylori+infection+and+gastric+cancer+mortalityen_HK
dc.identifier.emailWong, BCY: bcywong@hku.hk-
dc.identifier.emailChu, KM: chukm@hkucc.hku.hk-
dc.identifier.emailLam, SK: hrmelsk@hkucc.hku.hk-
dc.identifier.emailLai, KC: kclai@hku.hk-
dc.identifier.emailHu, WHC: hchu@hkucc.hku.hk-
dc.identifier.emailChing, CK: ckching@hkucc.hku.hk-
dc.identifier.authorityWong, BCY=rp00429-
dc.identifier.authorityChu, KM=rp00435-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/S0016-5085(98)82892-8-
dc.identifier.hkuros31634-
dc.identifier.hkuros33056-
dc.identifier.volume114-
dc.identifier.issuesuppl. 1-
dc.identifier.spageA705, abstract no. G2914-
dc.identifier.epageA705, abstract no. G2914-
dc.publisher.placeUnited States-
dc.identifier.issnl0016-5085-

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