Interacting protein of granulin-epithelin precursor in liver cancer

Abstract

BACKGROUND AND OBJECTIVE: Granulin-epithelin precursor (GEP), a novel growth factor, has been identified as a potential therapeutic target from our earlier genome-wide expression profile study on liver cancer. GEP over-expressed in liver cancer, and regulated proliferation, invasion and tumorigenesis. We demonstrated the therapeutic approach of GEP targeted therapy in human cancer using the home-made GEP monoclonal antibody on animal model, and GEP antibody showed dose-dependent inhibitory effect on tumor growth. However, the exact mechanism on how GEP executes its biological function, and in particular its interacting protein partners, is largely unknown. The present study aims to identify and characterize the GEP interacting protein ...