File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Prevalence and antifungal drug sensitivity of non-albicans Candida in oral rinse samples of self-caring elderly

TitlePrevalence and antifungal drug sensitivity of non-albicans Candida in oral rinse samples of self-caring elderly
Authors
Keywordselderly
non-albicans Candida
oral cavity
yeasts
Issue Date2011
PublisherWiley-Blackwell Publishing, Inc.. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=0734-0664&site=1
Citation
Gerodontology, 2011, v. 28 n. 4, p. 246-252 How to Cite?
AbstractTo assess the prevalence and antifungal drug sensitivity of non-albicans Candida (NAC) species in elderly outpatients. Materials and methods: We investigated oral rinse samples of 194 self-caring elderly population (mean age 83 years) with emphasis on background factors for harbouring NAC. Susceptibility of Candida species to antifungal drugs was determined using standard methodology. Multiple logistic regression analysis was performed taking positive NAC count as the dependent variable and a number of known Candida risk factors as independent variables. Results: Prevalence of candidal carriage of the population was 78.4%, of which 0.5% of the subjects were NAC positive. Candida dubliniensis was the most prevalent NAC species, followed by Candida glabrata and Candida parapsilosis. The NAC positive elderly were more often edentulous with dental prostheses or had fewer teeth than Candida albicans-positive or yeast-negative subjects. Dental caries slightly increased the risk for having NAC strains (odds ratio 1.08), whilst greater age appeared to lower the risk (odds ratio 0.77). Candida species were susceptible to the commonly used antifungal agents in general, but with considerable variation among species. Occasionally, some NAC exhibited lower antifungal susceptibility. Conclusion: The possibility of oral reservoirs of NAC strains which are resistant to common antifungals should be noted in elderly outpatients. © 2010 The Gerodontology Society and John Wiley & Sons A/S.
Persistent Identifierhttp://hdl.handle.net/10722/124446
ISSN
2023 Impact Factor: 2.0
2023 SCImago Journal Rankings: 0.609
ISI Accession Number ID
Funding AgencyGrant Number
GABA International Ltd, Therwil, Switzerland
Helsinki University Central Hospital (HUCH)EVO T1020V0015
Funding Information:

The study was supported by GABA International Ltd, Therwil, Switzerland. The author JHM was supported by the Helsinki University Central Hospital research funds (HUCH EVO T1020V0015).

References

 

DC FieldValueLanguage
dc.contributor.authorMeurman, JHen_HK
dc.contributor.authorPärnänen, Pen_HK
dc.contributor.authorSeneviratne, CJen_HK
dc.contributor.authorSamaranayake, LPen_HK
dc.contributor.authorSaarinen, AMJen_HK
dc.contributor.authorKari, Ken_HK
dc.date.accessioned2010-10-31T10:34:48Z-
dc.date.available2010-10-31T10:34:48Z-
dc.date.issued2011en_HK
dc.identifier.citationGerodontology, 2011, v. 28 n. 4, p. 246-252en_HK
dc.identifier.issn0734-0664en_HK
dc.identifier.urihttp://hdl.handle.net/10722/124446-
dc.description.abstractTo assess the prevalence and antifungal drug sensitivity of non-albicans Candida (NAC) species in elderly outpatients. Materials and methods: We investigated oral rinse samples of 194 self-caring elderly population (mean age 83 years) with emphasis on background factors for harbouring NAC. Susceptibility of Candida species to antifungal drugs was determined using standard methodology. Multiple logistic regression analysis was performed taking positive NAC count as the dependent variable and a number of known Candida risk factors as independent variables. Results: Prevalence of candidal carriage of the population was 78.4%, of which 0.5% of the subjects were NAC positive. Candida dubliniensis was the most prevalent NAC species, followed by Candida glabrata and Candida parapsilosis. The NAC positive elderly were more often edentulous with dental prostheses or had fewer teeth than Candida albicans-positive or yeast-negative subjects. Dental caries slightly increased the risk for having NAC strains (odds ratio 1.08), whilst greater age appeared to lower the risk (odds ratio 0.77). Candida species were susceptible to the commonly used antifungal agents in general, but with considerable variation among species. Occasionally, some NAC exhibited lower antifungal susceptibility. Conclusion: The possibility of oral reservoirs of NAC strains which are resistant to common antifungals should be noted in elderly outpatients. © 2010 The Gerodontology Society and John Wiley & Sons A/S.en_HK
dc.languageengen_HK
dc.publisherWiley-Blackwell Publishing, Inc.. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=0734-0664&site=1en_HK
dc.relation.ispartofGerodontologyen_HK
dc.subjectelderlyen_HK
dc.subjectnon-albicans Candidaen_HK
dc.subjectoral cavityen_HK
dc.subjectyeastsen_HK
dc.titlePrevalence and antifungal drug sensitivity of non-albicans Candida in oral rinse samples of self-caring elderlyen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0734-0664&volume=&spage=&epage=&date=2010&atitle=Prevalence+and+antifungal+drug+sensitivity+of+non-albicans+Candida+in+oral+rinse+samples+of+self-caring+elderlyen_HK
dc.identifier.emailSeneviratne, CJ:jaya@hku.hken_HK
dc.identifier.emailSamaranayake, LP:lakshman@hku.hken_HK
dc.identifier.authoritySeneviratne, CJ=rp01372en_HK
dc.identifier.authoritySamaranayake, LP=rp00023en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/j.1741-2358.2010.00407.xen_HK
dc.identifier.pmid20609005-
dc.identifier.scopuseid_2-s2.0-81555223114en_HK
dc.identifier.hkuros174179en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-81555223114&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume28en_HK
dc.identifier.issue4en_HK
dc.identifier.spage246en_HK
dc.identifier.epage252en_HK
dc.identifier.isiWOS:000297212000002-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridMeurman, JH=7006469347en_HK
dc.identifier.scopusauthoridPärnänen, P=24344880300en_HK
dc.identifier.scopusauthoridSeneviratne, CJ=6701897753en_HK
dc.identifier.scopusauthoridSamaranayake, LP=7102761002en_HK
dc.identifier.scopusauthoridSaarinen, AMJ=7004271333en_HK
dc.identifier.scopusauthoridKari, K=6603526983en_HK
dc.identifier.citeulike7604648-
dc.identifier.issnl0734-0664-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats