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Article: Bauhinia variegata var. variegata trypsin inhibitor: From isolation to potential medicinal applications

TitleBauhinia variegata var. variegata trypsin inhibitor: From isolation to potential medicinal applications
Authors
Fang, EFWong, JHBah, CSFLin, PTsao, SWNg, TB
KeywordsBauhinia variegata var. variegata
Cytokines
HIV
Nasopharyngeal carcinoma
Proteinase inhibitors
Issue Date2010
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/wps/find/journaldescription.cws_home/622790/description
Citation
Biochemical And Biophysical Research Communications, 2010, v. 396 n. 4, p. 806-811 How to Cite?
DOI: http://dx.doi.org/10.1016/j.bbrc.2010.04.140
AbstractHere we report for the first time of a new Kunitz-type trypsin inhibitor (termed BvvTI) from seeds of the Camel's foot tree, Bauhinia variegata var. variegata. BvvTI shares the same reactive site residues (Arg, Ser) and exhibits a homology of N-terminal amino acid sequence to other Bauhinia protease inhibitors. The trypsin inhibitory activity (K i, 0.1 × 10 -9 M) of BvvTI ranks the highest among them. Besides anti-HIV-1 reverse transcriptase activity, BvvTI could significantly inhibit the proliferation of nasopharyngeal cancer CNE-1 cells in a selective way. This may partially be contributed by its induction of cytokines and apoptotic bodies. These results unveil potential medicinal applications of BvvTI. © 2010 Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/124499
ISSN
0006-291X
2023 Impact Factor: 2.5
2023 SCImago Journal Rankings: 0.770
ISI Accession Number ID
WOS:000279125100005
Funding AgencyGrant Number
School of Biological Sciences, the University of Hong Kong
Funding Information:

We thank Dr. Carol P.Y. Lau, Prof. Lawrence Ramsden and Prof. Richard M.K. Saunders from School of Biological Sciences, the University of Hong Kong, for their kind support of the project.

References
References in Scopus

 

DC FieldValueLanguage
dc.contributor.authorFang, EFen_HK
dc.contributor.authorWong, JHen_HK
dc.contributor.authorBah, CSFen_HK
dc.contributor.authorLin, Pen_HK
dc.contributor.authorTsao, SWen_HK
dc.contributor.authorNg, TBen_HK
dc.date.accessioned2010-10-31T10:37:50Z-
dc.date.available2010-10-31T10:37:50Z-
dc.date.issued2010en_HK
dc.identifier.citationBiochemical And Biophysical Research Communications, 2010, v. 396 n. 4, p. 806-811en_HK
dc.identifier.issn0006-291Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/124499-
dc.description.abstractHere we report for the first time of a new Kunitz-type trypsin inhibitor (termed BvvTI) from seeds of the Camel's foot tree, Bauhinia variegata var. variegata. BvvTI shares the same reactive site residues (Arg, Ser) and exhibits a homology of N-terminal amino acid sequence to other Bauhinia protease inhibitors. The trypsin inhibitory activity (K i, 0.1 × 10 -9 M) of BvvTI ranks the highest among them. Besides anti-HIV-1 reverse transcriptase activity, BvvTI could significantly inhibit the proliferation of nasopharyngeal cancer CNE-1 cells in a selective way. This may partially be contributed by its induction of cytokines and apoptotic bodies. These results unveil potential medicinal applications of BvvTI. © 2010 Elsevier Inc. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/wps/find/journaldescription.cws_home/622790/descriptionen_HK
dc.relation.ispartofBiochemical and Biophysical Research Communicationsen_HK
dc.subjectBauhinia variegata var. variegataen_HK
dc.subjectCytokinesen_HK
dc.subjectHIVen_HK
dc.subjectNasopharyngeal carcinomaen_HK
dc.subjectProteinase inhibitorsen_HK
dc.subject.meshAnti-HIV Agents - chemistry - isolation and purification - pharmacology-
dc.subject.meshAntineoplastic Agents - chemistry - isolation and purification - pharmacology-
dc.subject.meshBauhinia - metabolism-
dc.subject.meshPeptides - chemistry - isolation and purification - pharmacology-
dc.subject.meshPlant Proteins - chemistry - isolation and purification - pharmacology-
dc.titleBauhinia variegata var. variegata trypsin inhibitor: From isolation to potential medicinal applicationsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0006-291X&volume=396&issue=4&spage=806&epage=811&date=2010&atitle=Bauhinia+variegata+var.+variegata+trypsin+inhibitor:+From+isolation+to+potential+medicinal+applicationsen_HK
dc.identifier.emailTsao, SW:gswtsao@hkucc.hku.hken_HK
dc.identifier.authorityTsao, SW=rp00399en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.bbrc.2010.04.140en_HK
dc.identifier.pmid20435016-
dc.identifier.scopuseid_2-s2.0-77953288202en_HK
dc.identifier.hkuros182821en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77953288202&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume396en_HK
dc.identifier.issue4en_HK
dc.identifier.spage806en_HK
dc.identifier.epage811en_HK
dc.identifier.isiWOS:000279125100005-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridFang, EF=35386218400en_HK
dc.identifier.scopusauthoridWong, JH=34874358200en_HK
dc.identifier.scopusauthoridBah, CSF=36672441000en_HK
dc.identifier.scopusauthoridLin, P=55228034700en_HK
dc.identifier.scopusauthoridTsao, SW=7102813116en_HK
dc.identifier.scopusauthoridNg, TB=35311803300en_HK
dc.identifier.issnl0006-291X-

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