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Article: Hirschsprung's disease

TitleHirschsprung's disease
Authors
Kenny, SETam, PKHGarciaBarcelo, M
KeywordsAganglionosis
Etiology
Genetics
Hirschprungs disease
Issue Date2010
PublisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/sempedsurg
Citation
Seminars In Pediatric Surgery, 2010, v. 19 n. 3, p. 194-200 How to Cite?
DOI: http://dx.doi.org/10.1053/j.sempedsurg.2010.03.004
AbstractHirschsprung's disease (HSCR) is characterized by absence of the enteric nervous system in a variable portion of the distal gut. Affected infants usually present in the days after birth with bowel obstruction. Despite surgical advances, long-term outcomes remain variable. In the last 2 decades, great advances have been made in understanding the genes and molecular biological mechanisms that underlie the disease. In addition, our understanding of normal enteric nervous system development and how motility develops in the developing fetus and infant has also increased. This review aims to draw these strands together to explain the developmental and biological basis of HSCR, and how this knowledge may be used in the future to aid children with HSCR. © 2010.
Persistent Identifierhttp://hdl.handle.net/10722/124525
ISSN
1055-8586
2023 Impact Factor: 1.4
2023 SCImago Journal Rankings: 0.431
ISI Accession Number ID
WOS:000279503100005
Funding AgencyGrant Number
Hong Kong Research Grants CouncilHKU 765407M
HKU 775907M
Action Medical Research
Medical Research Council
Children's Research Fund
Funding Information:

The authors would like to acknowledge the research grants HKU 765407M and HKU 775907M from the Hong Kong Research Grants Council to M.G B. and P T., respectively. S K. is supported by grants from Action Medical Research, Medical Research Council, and the Children's Research Fund

References
References in Scopus
Grants
Functional evaluation of RET coding and non-coding sequence mutations in Hirschsprung's disease
Genetic dissection of Hirschsprung's disease

 

DC FieldValueLanguage
dc.contributor.authorKenny, SEen_HK
dc.contributor.authorTam, PKHen_HK
dc.contributor.authorGarciaBarcelo, Men_HK
dc.date.accessioned2010-10-31T10:39:20Z-
dc.date.available2010-10-31T10:39:20Z-
dc.date.issued2010en_HK
dc.identifier.citationSeminars In Pediatric Surgery, 2010, v. 19 n. 3, p. 194-200en_HK
dc.identifier.issn1055-8586en_HK
dc.identifier.urihttp://hdl.handle.net/10722/124525-
dc.description.abstractHirschsprung's disease (HSCR) is characterized by absence of the enteric nervous system in a variable portion of the distal gut. Affected infants usually present in the days after birth with bowel obstruction. Despite surgical advances, long-term outcomes remain variable. In the last 2 decades, great advances have been made in understanding the genes and molecular biological mechanisms that underlie the disease. In addition, our understanding of normal enteric nervous system development and how motility develops in the developing fetus and infant has also increased. This review aims to draw these strands together to explain the developmental and biological basis of HSCR, and how this knowledge may be used in the future to aid children with HSCR. © 2010.en_HK
dc.languageengen_HK
dc.publisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/sempedsurgen_HK
dc.relation.ispartofSeminars in Pediatric Surgeryen_HK
dc.rightsNOTICE: this is the author’s version of a work that was accepted for publication in Seminars in Pediatric Surgery. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Seminars In Pediatric Surgery, 2010, v. 19 n. 3, p. 194-200. DOI: 10.1053/j.sempedsurg.2010.03.004-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectAganglionosisen_HK
dc.subjectEtiologyen_HK
dc.subjectGeneticsen_HK
dc.subjectHirschprungs diseaseen_HK
dc.subject.meshAbnormalities, Multiple - diagnosis - epidemiology - surgery-
dc.subject.meshDigestive System Abnormalities - diagnosis - epidemiology - surgery-
dc.subject.meshEnteric Nervous System - abnormalities-
dc.subject.meshGenetic Predisposition to Disease-
dc.subject.meshHirschsprung Disease - epidemiology - genetics - surgery-
dc.titleHirschsprung's diseaseen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1055-8586&volume=19&spage=194&epage=200&date=2010&atitle=Hirschsprung’s+diseaseen_HK
dc.identifier.emailTam, PKH: paultam@hkucc.hku.hken_HK
dc.identifier.emailGarciaBarcelo, M: mmgarcia@hkucc.hku.hken_HK
dc.identifier.authorityTam, PKH=rp00060en_HK
dc.identifier.authorityGarciaBarcelo, M=rp00445en_HK
dc.description.naturepostprinten_US
dc.identifier.doi10.1053/j.sempedsurg.2010.03.004en_HK
dc.identifier.pmid20610192-
dc.identifier.scopuseid_2-s2.0-77953933416en_HK
dc.identifier.hkuros173867en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77953933416&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume19en_HK
dc.identifier.issue3en_HK
dc.identifier.spage194en_HK
dc.identifier.epage200en_HK
dc.identifier.isiWOS:000279503100005-
dc.publisher.placeUnited Statesen_HK
dc.relation.projectFunctional evaluation of RET coding and non-coding sequence mutations in Hirschsprung's disease-
dc.relation.projectGenetic dissection of Hirschsprung's disease-
dc.identifier.scopusauthoridKenny, SE=7006325957en_HK
dc.identifier.scopusauthoridTam, PKH=7202539421en_HK
dc.identifier.scopusauthoridGarciaBarcelo, M=6701767303en_HK
dc.identifier.issnl1055-8586-

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