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Article: Impact of neoadjuvant treatment on total mesorectal excision for ultra-low rectal cancers
Title | Impact of neoadjuvant treatment on total mesorectal excision for ultra-low rectal cancers |
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Authors | |
Issue Date | 2010 |
Publisher | BioMed Central Ltd. The Journal's web site is located at http://www.wjso.com/home |
Citation | World Journal Of Surgical Oncology, 2010, v. 8 How to Cite? |
Abstract | Background: This study reviewed the impact of pre-operative chemoradiotherapy or post-operative chemotherapy and/or radiotherapy on total mesorectal excision (TME) for ultralow rectal cancers that required either low anterior resection with peranal coloanal anastomosis or abdomino-perineal resection (APR). We examined surgical complications, local recurrence and survival.Methods: Of the 1270 patients who underwent radical resection for rectal cancer from 1994 till 2007, 180 with tumors within 4 cm with either peranal coloanal anastomosis or APR were analyzed. Patients were compared in groups that had surgery only (Group A), pre-operative chemoradiotherapy (Group B), and post-operative therapy (Group C).Results: There were 115 males and the mean age was 65.43 years (range 30-89). APR was performed in 134 patients while 46 had a sphincter-preserving resection with peranal coloanal anastomosis. The mean follow-up period was 52.98 months (range: 0.57 to 178.9). There were 69, 58 and 53 patients in Groups A, B, and C, respectively. Nine patients in Group B could go on to have sphincter-saving rectal resection. The overall peri-operative complication rate was 43.4% in Group A vs. 29.3% in Group B vs. 39.6% in Group C, respectively. The local recurrence rate was significantly lower in Group B (8.6.9% vs. 21.7% in Group A vs. 33.9% in Group C) p < 0.05. The 5-year cancer-specific survival rates for Group A was 49.3%, Group B was 69.9% and Group C was 38.8% (p = 0.14).Conclusion: Pre-operative chemoradiation in low rectal cancer is not associated with a higher incidence of peri-operative complications and its benefits may include reduction local recurrence. © 2010 Lim et al; licensee BioMed Central Ltd. |
Persistent Identifier | http://hdl.handle.net/10722/125420 |
ISSN | 2023 Impact Factor: 2.5 2023 SCImago Journal Rankings: 0.733 |
PubMed Central ID | |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
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dc.contributor.author | Lim, YK | en_HK |
dc.contributor.author | Law, WL | en_HK |
dc.contributor.author | Liu, R | en_HK |
dc.contributor.author | Poon, JTC | en_HK |
dc.contributor.author | Fan, JFM | en_HK |
dc.contributor.author | Lo, OSH | en_HK |
dc.date.accessioned | 2010-10-31T11:30:25Z | - |
dc.date.available | 2010-10-31T11:30:25Z | - |
dc.date.issued | 2010 | en_HK |
dc.identifier.citation | World Journal Of Surgical Oncology, 2010, v. 8 | en_HK |
dc.identifier.issn | 1477-7819 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/125420 | - |
dc.description.abstract | Background: This study reviewed the impact of pre-operative chemoradiotherapy or post-operative chemotherapy and/or radiotherapy on total mesorectal excision (TME) for ultralow rectal cancers that required either low anterior resection with peranal coloanal anastomosis or abdomino-perineal resection (APR). We examined surgical complications, local recurrence and survival.Methods: Of the 1270 patients who underwent radical resection for rectal cancer from 1994 till 2007, 180 with tumors within 4 cm with either peranal coloanal anastomosis or APR were analyzed. Patients were compared in groups that had surgery only (Group A), pre-operative chemoradiotherapy (Group B), and post-operative therapy (Group C).Results: There were 115 males and the mean age was 65.43 years (range 30-89). APR was performed in 134 patients while 46 had a sphincter-preserving resection with peranal coloanal anastomosis. The mean follow-up period was 52.98 months (range: 0.57 to 178.9). There were 69, 58 and 53 patients in Groups A, B, and C, respectively. Nine patients in Group B could go on to have sphincter-saving rectal resection. The overall peri-operative complication rate was 43.4% in Group A vs. 29.3% in Group B vs. 39.6% in Group C, respectively. The local recurrence rate was significantly lower in Group B (8.6.9% vs. 21.7% in Group A vs. 33.9% in Group C) p < 0.05. The 5-year cancer-specific survival rates for Group A was 49.3%, Group B was 69.9% and Group C was 38.8% (p = 0.14).Conclusion: Pre-operative chemoradiation in low rectal cancer is not associated with a higher incidence of peri-operative complications and its benefits may include reduction local recurrence. © 2010 Lim et al; licensee BioMed Central Ltd. | en_HK |
dc.language | eng | en_HK |
dc.publisher | BioMed Central Ltd. The Journal's web site is located at http://www.wjso.com/home | en_HK |
dc.relation.ispartof | World Journal of Surgical Oncology | en_HK |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.rights | World Journal of Surgical Oncology. Copyright © BioMed Central Ltd. | - |
dc.subject.mesh | Adenocarcinoma - drug therapy - pathology - radiotherapy - therapy | - |
dc.subject.mesh | Antimetabolites, Antineoplastic - therapeutic use | - |
dc.subject.mesh | Digestive System Surgical Procedures | - |
dc.subject.mesh | Fluorouracil - therapeutic use | - |
dc.subject.mesh | Neoadjuvant Therapy | - |
dc.title | Impact of neoadjuvant treatment on total mesorectal excision for ultra-low rectal cancers | en_HK |
dc.type | Article | en_HK |
dc.identifier.openurl | http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1477-7819&volume=8&issue=23&spage=&epage=&date=2010&atitle=Impact+of+neoadjuvant+treatment+on+total+mesorectal+excision+for+ultra-low+rectal+cancers | en_HK |
dc.identifier.email | Law, WL: lawwl@hkucc.hku.hk | en_HK |
dc.identifier.email | Poon, JTC: tcjensen@hkucc.hku.hk | en_HK |
dc.identifier.authority | Law, WL=rp00436 | en_HK |
dc.identifier.authority | Poon, JTC=rp01603 | en_HK |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.1186/1477-7819-8-23 | en_HK |
dc.identifier.pmid | 20346160 | en_HK |
dc.identifier.pmcid | PMC2859360 | - |
dc.identifier.scopus | eid_2-s2.0-77952310022 | en_HK |
dc.identifier.hkuros | 175953 | en_HK |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-77952310022&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 8 | en_HK |
dc.identifier.issue | 23 | - |
dc.identifier.isi | WOS:000277430400001 | - |
dc.publisher.place | United Kingdom | en_HK |
dc.identifier.scopusauthorid | Lim, YK=34973264600 | en_HK |
dc.identifier.scopusauthorid | Law, WL=7103147867 | en_HK |
dc.identifier.scopusauthorid | Liu, R=15056333400 | en_HK |
dc.identifier.scopusauthorid | Poon, JTC=7005903722 | en_HK |
dc.identifier.scopusauthorid | Fan, JFM=36028123200 | en_HK |
dc.identifier.scopusauthorid | Lo, OSH=6508168045 | en_HK |
dc.identifier.citeulike | 6970746 | - |
dc.identifier.issnl | 1477-7819 | - |