Association of two adiponectin gene variants with ischemic stroke in a Chinese cohort

Abstract

Studies in many countries have shown an association between the plasma levels of adiponectin (AdipoQ) and the risk of cardiovascular disease, atherosclerosis and ischemic stroke (IS). However, the association between genetic variations in AdipoQ and IS has not been studied in Chinese. The aim of this study is to examine the association between single nucleotide polymorphisms (SNPs) of AdipoQ gene and ischemic stroke. A case-control study is being conducted in 310 Chinese with ischemic stroke and 310 sex- and age-matched controls with no documented ischemic heart disease and stroke. We examined on 5 SNPs of AdipoQ. All the SNPs in the cohort were detected by either TaqMan SNP genotyping assay or Sequenom. The GG genotype of rs266729 [OR: 2.31 (1.15-4.63), p-value: 0.018] and AA genotype of rs182052 [OR: 2.12 (1.26-3.57), p-value: 0.005] are significant higher risk of having ischemic stroke compare to dominant homozygous after adjusted with other risk factors. In conclusion, the recessive genotype of rs266729 and rs182052 associate with increased risk of IS in Chinese population.