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Conference Paper: Clinical course and outcomes of enterococcus peritonitis in peritoneal dialsyisi patient

TitleClinical course and outcomes of enterococcus peritonitis in peritoneal dialsyisi patient
Authors
KeywordsMedical sciences
Urology and nephrology
Issue Date2010
PublisherBlackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/NEP
Citation
The 12th Asian Pacific Congress of Nephrology (ACPN 2010), COEX, Seoul, Korea, 5-8 June 2010. In Nephrology, 2010, v. 15 suppl. S3, p. 47, abstract no. FP06-09 How to Cite?
AbstractINTRODUCTION: Enterococci are part of the normal flora of the gastrointestinal tract. They can lead to enteric peritonitis which is a serious complication of peritoneal dialysis (PD). However, the clinical course and outcomes of PD-related Enterococcus peritonitis remains unclear. METHODS: We reviewed all Enterococcus peritonitis in our dialysis unit from 1995 to 2009. RESULTS: During the study period, 1421 episodes of peritonitis were recorded. A total of 29 episodes were due to single-organism Enterococcus; 12 episodes were caused by E. faecalis while nine episodes were caused by E. faecium. The overall ampicillin-resistant rate was 41.4%. Recent use of antibiotics was associated with the development of ampicillin-resistant Enterococcus (ARE) peritonitis (hazard ratio 12.53, P = 0.04). The primary response rate of Entereococcus peritonitis was significantly higher than that of Escherichia coli peritonitis (89.7% versus 69.9%, P = 0.038). When compared with ampicillin-susceptible Enterococcus (ASE) peritonitis, the primary response rate of ARE peritonitis was not significantly lower (83.3% versus 94.1%, P = 0.553). However, significantly more patients in ARE group had received vancomycin (83.3% versus 23.5%, P = 0.003) with a longer mean treatment duration (3.7 ± 6.8 days versus 11.8 ± 6.9 days, P = 0.005). CONCLUSION: Recent use of antibiotics is a risk factor for the development of ARE peritonitis. When compared with ASE peritonitis, ARE peritonitis had similar outcomes but vancomycin was required during treatment which may in turn predispose patients to infections caused by vancomycin-resistant organisms.
DescriptionOral Presentation
Persistent Identifierhttp://hdl.handle.net/10722/126401
ISSN
2023 Impact Factor: 2.4
2023 SCImago Journal Rankings: 0.641

 

DC FieldValueLanguage
dc.contributor.authorYip, TPSen_HK
dc.contributor.authorTse, KCen_HK
dc.contributor.authorNg, Fen_HK
dc.contributor.authorLam, MFen_HK
dc.contributor.authorTang, Sen_HK
dc.contributor.authorLui, SLen_HK
dc.contributor.authorLai, KNen_HK
dc.contributor.authorChan, TMen_HK
dc.contributor.authorLo, WKen_HK
dc.date.accessioned2010-10-31T12:26:29Z-
dc.date.available2010-10-31T12:26:29Z-
dc.date.issued2010en_HK
dc.identifier.citationThe 12th Asian Pacific Congress of Nephrology (ACPN 2010), COEX, Seoul, Korea, 5-8 June 2010. In Nephrology, 2010, v. 15 suppl. S3, p. 47, abstract no. FP06-09en_HK
dc.identifier.issn1320-5358en_HK
dc.identifier.urihttp://hdl.handle.net/10722/126401-
dc.descriptionOral Presentation-
dc.description.abstractINTRODUCTION: Enterococci are part of the normal flora of the gastrointestinal tract. They can lead to enteric peritonitis which is a serious complication of peritoneal dialysis (PD). However, the clinical course and outcomes of PD-related Enterococcus peritonitis remains unclear. METHODS: We reviewed all Enterococcus peritonitis in our dialysis unit from 1995 to 2009. RESULTS: During the study period, 1421 episodes of peritonitis were recorded. A total of 29 episodes were due to single-organism Enterococcus; 12 episodes were caused by E. faecalis while nine episodes were caused by E. faecium. The overall ampicillin-resistant rate was 41.4%. Recent use of antibiotics was associated with the development of ampicillin-resistant Enterococcus (ARE) peritonitis (hazard ratio 12.53, P = 0.04). The primary response rate of Entereococcus peritonitis was significantly higher than that of Escherichia coli peritonitis (89.7% versus 69.9%, P = 0.038). When compared with ampicillin-susceptible Enterococcus (ASE) peritonitis, the primary response rate of ARE peritonitis was not significantly lower (83.3% versus 94.1%, P = 0.553). However, significantly more patients in ARE group had received vancomycin (83.3% versus 23.5%, P = 0.003) with a longer mean treatment duration (3.7 ± 6.8 days versus 11.8 ± 6.9 days, P = 0.005). CONCLUSION: Recent use of antibiotics is a risk factor for the development of ARE peritonitis. When compared with ASE peritonitis, ARE peritonitis had similar outcomes but vancomycin was required during treatment which may in turn predispose patients to infections caused by vancomycin-resistant organisms.-
dc.languageengen_HK
dc.publisherBlackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/NEP-
dc.relation.ispartofNephrologyen_HK
dc.rightsThe definitive version is available at www.blackwell-synergy.com-
dc.subjectMedical sciences-
dc.subjectUrology and nephrology-
dc.titleClinical course and outcomes of enterococcus peritonitis in peritoneal dialsyisi patienten_HK
dc.typeConference_Paperen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1320-5358&volume=15&issue=suppl. S3&spage=47&epage=&date=2010&atitle=Clinical+course+and+outcomes+of+enterococcus+peritonitis+in+peritoneal+dialsyisi+patienten_HK
dc.identifier.emailYip, TPS: tpsyip@hku.hken_HK
dc.identifier.emailLam, MF: feimflam@hku.hken_HK
dc.identifier.emailTang, S: scwtang@hku.hken_HK
dc.identifier.emailLui, SL: sllui@HKUCC.hku.hken_HK
dc.identifier.emailLai, KN: knlai@hku.hken_HK
dc.identifier.emailChan, TM: dtmchan@hku.hken_HK
dc.identifier.emailLo, WK: wkloc@HKUCC.hku.hk-
dc.identifier.authorityTang, S=rp00480en_HK
dc.identifier.authorityLai, KN=rp00324en_HK
dc.identifier.authorityChan, TM=rp00394en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1111/j.1440-1797.2010.01336.x-
dc.identifier.hkuros174063en_HK
dc.identifier.volume15en_HK
dc.identifier.issuesuppl. S3en_HK
dc.identifier.spage47, abstract no. FP06-09-
dc.identifier.epage47, abstract no. FP06-09-
dc.description.otherThe 12th Asian Pacific Congress of Nephrology (ACPN 2010), COEX, Seoul, Korea, 5-8 June 2010. In Nephrology, 2010, v. 15 n. suppl. S3, p. 47, abstract no. FP06-09-
dc.identifier.issnl1320-5358-

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