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Article: A subpopulation of CD26 + cancer stem cells with metastatic capacity in human colorectal cancer

TitleA subpopulation of CD26 + cancer stem cells with metastatic capacity in human colorectal cancer
Authors
Pang, RLaw, WLChu, ACYPoon, JTLam, CSCChow, AKMNg, LCheung, LWHLan, XRLan, HYTan, VPYYau, TCPoon, RTWong, BCY
KeywordsAntigen Expression
Cancer Combination Chemotherapy
Cancer Stem Cell
Cell Invasion
Colorectal Cancer
Issue Date2010
PublisherCell Press. The Journal's web site is located at http://www.cellstemcell.com
Citation
Cell Stem Cell, 2010, v. 6 n. 6, p. 603-615 How to Cite?
DOI: http://dx.doi.org/10.1016/j.stem.2010.04.001
AbstractRecent evidence suggests that a subpopulation of cancer cells, cancer stem cells (CSCs), is responsible for tumor growth in colorectal cancer. However, the role of CSCs in colorectal cancer metastasis is unclear. Here, we identified a subpopulation of CD26 + cells uniformly present in both the primary and metastatic tumors in colorectal cancer patients with liver metastasis. Furthermore, in patients without distant metastasis at the time of presentation, the presence of CD26 + cells in their primary tumors predicted distant metastasis on follow-up. Isolated CD26 + cells, but not CD26 - cells, led to development of distant metastasis when injected into the mouse cecal wall. CD26 + cells were also associated with enhanced invasiveness and chemoresistance. Our findings have uncovered a critical role of CSCs in metastatic progression of cancer. Furthermore, the ability to predict metastasis based on analysis of CSC subsets in the primary tumor may have important clinical implication as a selection criterion for adjuvant therapy. © 2010 Elsevier Inc.
Persistent Identifierhttp://hdl.handle.net/10722/132475
ISSN
1934-5909
2021 Impact Factor: 25.269
2020 SCImago Journal Rankings: 8.860
ISI Accession Number ID
WOS:000278840700020
Funding AgencyGrant Number
Strategic Research Theme of Cancer
Seed Funding Research Grant
University of Hong Kong
Funding Information:

We thank A.M. Cheung for technical assistance in flow cytometry analysis, R. De Maria and X.W. Wang for critical discussion of the manuscript, A. Chan and S.Y. Fan for specimen collection, and G.S.W. Tsao for support. This study is supported by Strategic Research Theme of Cancer, Seed Funding Research Grant, and Donation of the Li Ka Shing Foundation of Matching Grants of The University of Hong Kong.

References
References in Scopus

 

DC FieldValueLanguage
dc.contributor.authorPang, Ren_HK
dc.contributor.authorLaw, WLen_HK
dc.contributor.authorChu, ACYen_HK
dc.contributor.authorPoon, JTen_HK
dc.contributor.authorLam, CSCen_HK
dc.contributor.authorChow, AKMen_HK
dc.contributor.authorNg, Len_HK
dc.contributor.authorCheung, LWHen_HK
dc.contributor.authorLan, XRen_HK
dc.contributor.authorLan, HYen_HK
dc.contributor.authorTan, VPYen_HK
dc.contributor.authorYau, TCen_HK
dc.contributor.authorPoon, RTen_HK
dc.contributor.authorWong, BCYen_HK
dc.date.accessioned2011-03-28T09:25:08Z-
dc.date.available2011-03-28T09:25:08Z-
dc.date.issued2010en_HK
dc.identifier.citationCell Stem Cell, 2010, v. 6 n. 6, p. 603-615en_HK
dc.identifier.issn1934-5909en_HK
dc.identifier.urihttp://hdl.handle.net/10722/132475-
dc.description.abstractRecent evidence suggests that a subpopulation of cancer cells, cancer stem cells (CSCs), is responsible for tumor growth in colorectal cancer. However, the role of CSCs in colorectal cancer metastasis is unclear. Here, we identified a subpopulation of CD26 + cells uniformly present in both the primary and metastatic tumors in colorectal cancer patients with liver metastasis. Furthermore, in patients without distant metastasis at the time of presentation, the presence of CD26 + cells in their primary tumors predicted distant metastasis on follow-up. Isolated CD26 + cells, but not CD26 - cells, led to development of distant metastasis when injected into the mouse cecal wall. CD26 + cells were also associated with enhanced invasiveness and chemoresistance. Our findings have uncovered a critical role of CSCs in metastatic progression of cancer. Furthermore, the ability to predict metastasis based on analysis of CSC subsets in the primary tumor may have important clinical implication as a selection criterion for adjuvant therapy. © 2010 Elsevier Inc.en_HK
dc.languageengen_US
dc.publisherCell Press. The Journal's web site is located at http://www.cellstemcell.comen_HK
dc.relation.ispartofCell Stem Cellen_HK
dc.subjectAntigen Expressionen_US
dc.subjectCancer Combination Chemotherapy-
dc.subjectCancer Stem Cell-
dc.subjectCell Invasion-
dc.subjectColorectal Cancer-
dc.titleA subpopulation of CD26 + cancer stem cells with metastatic capacity in human colorectal canceren_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1934-5909&volume=6&issue=6&spage=603&epage=615&date=2010&atitle=A+subpopulation+of+CD26++cancer+stem+cells+with+metastatic+capacity+in+human+colorectal+cancer-
dc.identifier.emailPang, R: robertap@hkucc.hku.hken_HK
dc.identifier.emailLaw, WL: lawwl@hkucc.hku.hken_HK
dc.identifier.emailPoon, JT: tcjensen@hkucc.hku.hken_HK
dc.identifier.emailTan, VPY: vpytan@hku.hken_HK
dc.identifier.emailYau, TC: tyaucc@hku.hken_HK
dc.identifier.emailPoon, RT: poontp@hkucc.hku.hken_HK
dc.identifier.emailWong, BCY: bcywong@hku.hken_HK
dc.identifier.authorityPang, R=rp00274en_HK
dc.identifier.authorityLaw, WL=rp00436en_HK
dc.identifier.authorityPoon, JT=rp01603en_HK
dc.identifier.authorityTan, VPY=rp01458en_HK
dc.identifier.authorityYau, TC=rp01466en_HK
dc.identifier.authorityPoon, RT=rp00446en_HK
dc.identifier.authorityWong, BCY=rp00429en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.stem.2010.04.001en_HK
dc.identifier.pmid20569697-
dc.identifier.scopuseid_2-s2.0-77956641496en_HK
dc.identifier.hkuros173427-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77956641496&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume6en_HK
dc.identifier.issue6en_HK
dc.identifier.spage603en_HK
dc.identifier.epage615en_HK
dc.identifier.isiWOS:000278840700020-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridPang, R=7004376659en_HK
dc.identifier.scopusauthoridLaw, WL=7103147867en_HK
dc.identifier.scopusauthoridChu, ACY=36657034500en_HK
dc.identifier.scopusauthoridPoon, JT=7005903722en_HK
dc.identifier.scopusauthoridLam, CSC=35332626500en_HK
dc.identifier.scopusauthoridChow, AKM=36656984900en_HK
dc.identifier.scopusauthoridNg, L=36450962500en_HK
dc.identifier.scopusauthoridCheung, LWH=36656866300en_HK
dc.identifier.scopusauthoridLan, XR=36657568600en_HK
dc.identifier.scopusauthoridLan, HY=24544799000en_HK
dc.identifier.scopusauthoridTan, VPY=24449627600en_HK
dc.identifier.scopusauthoridYau, TC=23391533100en_HK
dc.identifier.scopusauthoridPoon, RT=7103097223en_HK
dc.identifier.scopusauthoridWong, BCY=7402023340en_HK
dc.identifier.issnl1875-9777-

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