Application of a Nano-antimicrobial film to prevent ventilator-associated pneumonia: A pilot study

Abstract

Ventilator-associated pneumonia (VAP) is one of the most common hospital-associated infections and has accounted for approximately 15% of all hospital-associated infections. In 76% of the VAP cases, the same bacteria colonize the oral cavity and lungs. Oral care interventions may play a role in the prevention of VAP, yet more than half of the hospitals do not have specific policies for the oral care of intubated patients. Oral cavity interlinks with respiratory tracts and digestive tracts. After surgery has been performed in these areas, aerobic and anaerobic bacteria frequently induce operative wound infections in teeth, gingiva and supporting tissues of the teeth and tonsils. This study investigates the effects of a nanotechnology antimicrobial spray (JUC) on the incidence of VAP. 320 patients diagnosed with VAP were randomly divided into treatment and control groups. After using chlorhexidine mouthrinse, the treatment group used a nanotechnology antimicrobial spray to the nose and mouth. The control group was given normal saline. The incidence rate of VAP was significantly lower in the treatment (8.38%) than control group (54.24%) (p<0.01). A physical antimicrobial film is formed on the surface of oral and nasal mucosa after using the JUC spray which effectively reduces the microbial colonization in the sprayed areas, thus reducing and delaying the incidence of VAP. © 2011 Academic Journals.