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Article: Renal function and renotropic effects of secretin in cystic fibrosis.
Title | Renal function and renotropic effects of secretin in cystic fibrosis. |
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Authors | |
Issue Date | 1997 |
Publisher | Holzapfel Verlag GmbH. |
Citation | European Journal Of Medical Research, 1997, v. 2 n. 10, p. 431-436 How to Cite? |
Abstract | In ten cystic fibrosis patients and nine age-matched controls, renal function was determined before and after infusion of secretin. Under baseline conditions creatinine excretion and clearance were significantly elevated, exclusively due to those patients who were homozygous for the DF508 mutation (153 vs 132 ml/min*1.73m2), whereas the glomerular filtration rate, measured by inulin clearance showed no difference. Renal plasma flow and the fractional reabsorption rates of electrolytes were similar in patients and controls. During secretin infusion renal plasma flow increased and the fractional reabsorption rates of electrolytes decreased in both groups. The patients had a increased metabolic clearance (2900 vs 1660 ml/min*m2) and endogenous production rate (9,9 vs 2,5 pmol/min*m2) of of secretin. In conclusion global renal function and electrolyte handling, in particular chloride permeability, are unchanged in cystic fibrosis. Individuals expressing the DF508 genotype showed a selective elevation of creatinine excretion and clearance. The secretion and metabolic clearance of secretin are increased in cystic fibrosis. |
Persistent Identifier | http://hdl.handle.net/10722/133917 |
ISSN | 2023 Impact Factor: 2.8 2023 SCImago Journal Rankings: 0.736 |
DC Field | Value | Language |
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dc.contributor.author | Windstetter, D | en_HK |
dc.contributor.author | Schaefer, F | en_HK |
dc.contributor.author | Schärer, K | en_HK |
dc.contributor.author | Reiter, K | en_HK |
dc.contributor.author | Eife, R | en_HK |
dc.contributor.author | Harms, HK | en_HK |
dc.contributor.author | BerteleHarms, R | en_HK |
dc.contributor.author | Fiedler, F | en_HK |
dc.contributor.author | Tsui, LC | en_HK |
dc.contributor.author | Reitmeir, P | en_HK |
dc.contributor.author | Horster, M | en_HK |
dc.contributor.author | Hadorn, HB | en_HK |
dc.date.accessioned | 2011-06-07T03:25:38Z | - |
dc.date.available | 2011-06-07T03:25:38Z | - |
dc.date.issued | 1997 | en_HK |
dc.identifier.citation | European Journal Of Medical Research, 1997, v. 2 n. 10, p. 431-436 | en_HK |
dc.identifier.issn | 0949-2321 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/133917 | - |
dc.description.abstract | In ten cystic fibrosis patients and nine age-matched controls, renal function was determined before and after infusion of secretin. Under baseline conditions creatinine excretion and clearance were significantly elevated, exclusively due to those patients who were homozygous for the DF508 mutation (153 vs 132 ml/min*1.73m2), whereas the glomerular filtration rate, measured by inulin clearance showed no difference. Renal plasma flow and the fractional reabsorption rates of electrolytes were similar in patients and controls. During secretin infusion renal plasma flow increased and the fractional reabsorption rates of electrolytes decreased in both groups. The patients had a increased metabolic clearance (2900 vs 1660 ml/min*m2) and endogenous production rate (9,9 vs 2,5 pmol/min*m2) of of secretin. In conclusion global renal function and electrolyte handling, in particular chloride permeability, are unchanged in cystic fibrosis. Individuals expressing the DF508 genotype showed a selective elevation of creatinine excretion and clearance. The secretion and metabolic clearance of secretin are increased in cystic fibrosis. | en_HK |
dc.language | eng | - |
dc.publisher | Holzapfel Verlag GmbH. | - |
dc.relation.ispartof | European journal of medical research | en_HK |
dc.subject.mesh | Cystic Fibrosis - genetics - physiopathology | - |
dc.subject.mesh | Electrolytes - metabolism | - |
dc.subject.mesh | Kidney - drug effects - physiopathology | - |
dc.subject.mesh | Renal Plasma Flow - drug effects | - |
dc.subject.mesh | Secretin - administration and dosage - diagnostic use - physiology | - |
dc.title | Renal function and renotropic effects of secretin in cystic fibrosis. | en_HK |
dc.type | Article | en_HK |
dc.identifier.openurl | http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0949-2321&volume=2&issue=10&spage=431&epage=436&date=1997&atitle=Renal+function+and+renotropic+effects+of+secretin+in+cystic+fibrosis | - |
dc.identifier.email | Tsui, LC: tsuilc@hkucc.hku.hk | en_HK |
dc.identifier.authority | Tsui, LC=rp00058 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.pmid | 9348270 | - |
dc.identifier.scopus | eid_2-s2.0-0031591940 | en_HK |
dc.identifier.hkuros | 121070 | - |
dc.identifier.volume | 2 | en_HK |
dc.identifier.issue | 10 | en_HK |
dc.identifier.spage | 431 | en_HK |
dc.identifier.epage | 436 | en_HK |
dc.identifier.scopusauthorid | Windstetter, D=36839397000 | en_HK |
dc.identifier.scopusauthorid | Schaefer, F=7103383884 | en_HK |
dc.identifier.scopusauthorid | Schärer, K=7101998734 | en_HK |
dc.identifier.scopusauthorid | Reiter, K=7006735445 | en_HK |
dc.identifier.scopusauthorid | Eife, R=7004137708 | en_HK |
dc.identifier.scopusauthorid | Harms, HK=7103319049 | en_HK |
dc.identifier.scopusauthorid | BerteleHarms, R=6602823539 | en_HK |
dc.identifier.scopusauthorid | Fiedler, F=7103026114 | en_HK |
dc.identifier.scopusauthorid | Tsui, LC=7102754167 | en_HK |
dc.identifier.scopusauthorid | Reitmeir, P=6701599480 | en_HK |
dc.identifier.scopusauthorid | Horster, M=7006948694 | en_HK |
dc.identifier.scopusauthorid | Hadorn, HB=6701786387 | en_HK |
dc.identifier.issnl | 0949-2321 | - |