File Download
  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Abnormalities in connectivity of white-matter tracts in patients with familial and non-familial schizophrenia

TitleAbnormalities in connectivity of white-matter tracts in patients with familial and non-familial schizophrenia
Authors
KeywordsDTI
family history
first episode
fractional anisotropy
schizophrenia
voxel-based analysis
Issue Date2011
PublisherCambridge University Press. The Journal's web site is located at http://journals.cambridge.org/action/displayJournal?jid=PSM
Citation
Psychological Medicine, 2011, v. 41 n. 8, p. 1691-1700 How to Cite?
AbstractBackground Abnormalities in the connectivity of white-matter (WM) tracts in schizophrenia are supported by evidence from post-mortem investigations, functional and structural magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI). The aims of this study were to explore the microstructural changes in first-episode schizophrenia in a Han Chinese population and to investigate whether a family history of psychiatric disorder is related to the severity of WM tract integrity abnormalities in these patients.Method T1-weighted MR and DT images were collected in 68 patients with first-episode schizophrenia [22 with a positive family history (PFH) and 46 with a negative family history (NFH)] and 100 healthy controls. Voxel-based analysis was performed and WM integrity was quantified by fractional anisotropy (FA). Cluster-and voxel-level analyses were performed by using two-sample t tests between patients and controls and/or using a full factorial model with one factor and three levels among the three sample groups (patients with PFH or NFH, and controls), as appropriate.Results FA deficits were observed in the patient group, especially in the left temporal lobe and right corpus callosum. This effect was more severe in the non-familial schizophrenia than in the familial schizophrenia subgroup.Conclusions Overall, these findings support the hypothesis that loss of WM integrity may be an important pathophysiological feature of schizophrenia, with particular implications for brain dysmaturation in non-familial and familial schizophrenia. © 2011 Cambridge University Press.
Persistent Identifierhttp://hdl.handle.net/10722/135413
ISSN
2023 Impact Factor: 5.9
2023 SCImago Journal Rankings: 2.768
ISI Accession Number ID
Funding AgencyGrant Number
National Nature Science Foundation of China30 971 056
30 530 300
30 125 014
National Basic Research Programme of China (973 Programme)2007CB512301
2007CB512305
NARSAD
Wellcome Trust
Funding Information:

This work was funded partly by the National Nature Science Foundation of China (grant 30 971 056 to W. Q.; grants 30 530 300 and 30 125 014 to T. L.), the National Basic Research Programme of China (973 Programme 2007CB512301 to T. L.; 2007CB512305 to Q. G.), the NARSAD Independent Investigator Award (T. L.), and the Wellcome Trust (International Collaborative Award to T. L., D. A. C. and X. L.). We also thank two anonymous reviewers for their comprehensive comments, which greatly improved the manuscript.

References

 

DC FieldValueLanguage
dc.contributor.authorWang, Qen_HK
dc.contributor.authorDeng, Wen_HK
dc.contributor.authorHuang, Cen_HK
dc.contributor.authorLi, Men_HK
dc.contributor.authorMa, Xen_HK
dc.contributor.authorWang, Yen_HK
dc.contributor.authorJiang, Len_HK
dc.contributor.authorLui, Sen_HK
dc.contributor.authorHuang, Xen_HK
dc.contributor.authorChua, SEen_HK
dc.contributor.authorCheung, Cen_HK
dc.contributor.authorMcAlonan, GMen_HK
dc.contributor.authorSham, PCen_HK
dc.contributor.authorMurray, RMen_HK
dc.contributor.authorCollier, DAen_HK
dc.contributor.authorGong, Qen_HK
dc.contributor.authorLi, Ten_HK
dc.date.accessioned2011-07-27T01:34:51Z-
dc.date.available2011-07-27T01:34:51Z-
dc.date.issued2011en_HK
dc.identifier.citationPsychological Medicine, 2011, v. 41 n. 8, p. 1691-1700en_HK
dc.identifier.issn0033-2917en_HK
dc.identifier.urihttp://hdl.handle.net/10722/135413-
dc.description.abstractBackground Abnormalities in the connectivity of white-matter (WM) tracts in schizophrenia are supported by evidence from post-mortem investigations, functional and structural magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI). The aims of this study were to explore the microstructural changes in first-episode schizophrenia in a Han Chinese population and to investigate whether a family history of psychiatric disorder is related to the severity of WM tract integrity abnormalities in these patients.Method T1-weighted MR and DT images were collected in 68 patients with first-episode schizophrenia [22 with a positive family history (PFH) and 46 with a negative family history (NFH)] and 100 healthy controls. Voxel-based analysis was performed and WM integrity was quantified by fractional anisotropy (FA). Cluster-and voxel-level analyses were performed by using two-sample t tests between patients and controls and/or using a full factorial model with one factor and three levels among the three sample groups (patients with PFH or NFH, and controls), as appropriate.Results FA deficits were observed in the patient group, especially in the left temporal lobe and right corpus callosum. This effect was more severe in the non-familial schizophrenia than in the familial schizophrenia subgroup.Conclusions Overall, these findings support the hypothesis that loss of WM integrity may be an important pathophysiological feature of schizophrenia, with particular implications for brain dysmaturation in non-familial and familial schizophrenia. © 2011 Cambridge University Press.en_HK
dc.languageengen_US
dc.publisherCambridge University Press. The Journal's web site is located at http://journals.cambridge.org/action/displayJournal?jid=PSMen_HK
dc.relation.ispartofPsychological Medicineen_HK
dc.rightsPsychological Medicine. Copyright © Cambridge University Press.-
dc.subjectDTIen_HK
dc.subjectfamily historyen_HK
dc.subjectfirst episodeen_HK
dc.subjectfractional anisotropyen_HK
dc.subjectschizophreniaen_HK
dc.subjectvoxel-based analysisen_HK
dc.subject.meshBrain - pathology-
dc.subject.meshChi-Square Distribution-
dc.subject.meshDiffusion Tensor Imaging-
dc.subject.meshMagnetic Resonance Imaging-
dc.subject.meshSchizophrenia - genetics - pathology-
dc.titleAbnormalities in connectivity of white-matter tracts in patients with familial and non-familial schizophreniaen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0033-2917&volume=41&issue=8&spage=1691&epage=1700&date=2010&atitle=Abnormalities+in+connectivity+of+white-matter+tracts+in+patients+with+familial+and+non-familial+schizophrenia.-
dc.identifier.emailChua, SE: sechua@hku.hken_HK
dc.identifier.emailCheung, C: charlton@hkucc.hku.hken_HK
dc.identifier.emailMcAlonan, GM: mcalonan@hkucc.hku.hken_HK
dc.identifier.emailSham, PC: pcsham@hku.hken_HK
dc.identifier.authorityChua, SE=rp00438en_HK
dc.identifier.authorityCheung, C=rp01574en_HK
dc.identifier.authorityMcAlonan, GM=rp00475en_HK
dc.identifier.authoritySham, PC=rp00459en_HK
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1017/S0033291710002412en_HK
dc.identifier.pmid21205362-
dc.identifier.scopuseid_2-s2.0-80054966968en_HK
dc.identifier.hkuros187271en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-80054966968&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume41en_HK
dc.identifier.issue8en_HK
dc.identifier.spage1691en_HK
dc.identifier.epage1700en_HK
dc.identifier.isiWOS:000292704400011-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridWang, Q=54387684100en_HK
dc.identifier.scopusauthoridDeng, W=36598255000en_HK
dc.identifier.scopusauthoridHuang, C=54386865700en_HK
dc.identifier.scopusauthoridLi, M=54386994400en_HK
dc.identifier.scopusauthoridMa, X=35354066000en_HK
dc.identifier.scopusauthoridWang, Y=54387845700en_HK
dc.identifier.scopusauthoridJiang, L=8436782700en_HK
dc.identifier.scopusauthoridLui, S=23978614700en_HK
dc.identifier.scopusauthoridHuang, X=7410246375en_HK
dc.identifier.scopusauthoridChua, SE=7201550427en_HK
dc.identifier.scopusauthoridCheung, C=7202061845en_HK
dc.identifier.scopusauthoridMcAlonan, GM=6603123011en_HK
dc.identifier.scopusauthoridSham, PC=34573429300en_HK
dc.identifier.scopusauthoridMurray, RM=35406239400en_HK
dc.identifier.scopusauthoridCollier, DA=26642980600en_HK
dc.identifier.scopusauthoridGong, Q=7201440871en_HK
dc.identifier.scopusauthoridLi, T=36072008200en_HK
dc.identifier.issnl0033-2917-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats