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- Publisher Website: 10.1177/0269881110376685
- Scopus: eid_2-s2.0-79955445368
- PMID: 20826552
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Article: Effects on prolongation of Bazett's corrected QT interval of seven second-generation antipsychotics in the treatment of schizophrenia: A meta-analysis
Title | Effects on prolongation of Bazett's corrected QT interval of seven second-generation antipsychotics in the treatment of schizophrenia: A meta-analysis |
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Authors | |
Keywords | Bazett's correction meta-analysis QT interval Second-generation antipsychotics |
Issue Date | 2011 |
Publisher | Sage Publications Ltd.. The Journal's web site is located at http://jop.sagepub.com |
Citation | Journal Of Psychopharmacology, 2011, v. 25 n. 5, p. 646-666 How to Cite? |
Abstract | The use of second-generation antipsychotics (SGAs) for the treatment of schizophrenia has surged worldwide. Amisulpride, aripiprazole, olanzapine, quetiapine, risperidone, sertindole and ziprasidone have now been commonly prescribed. Their effects on QT interval differ but evidence remains sparse and mostly inconclusive. Since prolongation of heart-rate corrected QT interval has been implicated as an useful surrogate marker to predict drug-related cardiac mortality and pro-arrhythmic potentials, it is timely and necessary to compare the effects of Bazett's corrected QT interval (QT Bc) prolongation for the commonly prescribed SGAs. A meta-analysis was conducted according to suggestions by the Quality of Reporting of Meta-analysis group with literature identified using various databases and augmented with hand-searching to assess the magnitude and risk on QT Bc prolongation by these seven SGAs for treatments in adult subjects with schizophrenia. Because of incomplete QT Bc data reporting, quetiapine could not be assessed by the meta-analytical approach in this study. Aripiprazole was the only SGA associated with both statistically significant lower risk and mean change in QT Bc, with sertindole giving a statistically significant worsening effect on mean QT Bc. Other analyses did not demonstrate any statistically significant pooled effects for the studied SGAs, neither on the magnitude over mean or mean change, nor the risk on QT Bc prolongation. © 2011 The Author(s). |
Persistent Identifier | http://hdl.handle.net/10722/135419 |
ISSN | 2023 Impact Factor: 4.5 2023 SCImago Journal Rankings: 1.366 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Chung, AK | en_HK |
dc.contributor.author | Chua, SE | en_HK |
dc.date.accessioned | 2011-07-27T01:34:55Z | - |
dc.date.available | 2011-07-27T01:34:55Z | - |
dc.date.issued | 2011 | en_HK |
dc.identifier.citation | Journal Of Psychopharmacology, 2011, v. 25 n. 5, p. 646-666 | en_HK |
dc.identifier.issn | 0269-8811 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/135419 | - |
dc.description.abstract | The use of second-generation antipsychotics (SGAs) for the treatment of schizophrenia has surged worldwide. Amisulpride, aripiprazole, olanzapine, quetiapine, risperidone, sertindole and ziprasidone have now been commonly prescribed. Their effects on QT interval differ but evidence remains sparse and mostly inconclusive. Since prolongation of heart-rate corrected QT interval has been implicated as an useful surrogate marker to predict drug-related cardiac mortality and pro-arrhythmic potentials, it is timely and necessary to compare the effects of Bazett's corrected QT interval (QT Bc) prolongation for the commonly prescribed SGAs. A meta-analysis was conducted according to suggestions by the Quality of Reporting of Meta-analysis group with literature identified using various databases and augmented with hand-searching to assess the magnitude and risk on QT Bc prolongation by these seven SGAs for treatments in adult subjects with schizophrenia. Because of incomplete QT Bc data reporting, quetiapine could not be assessed by the meta-analytical approach in this study. Aripiprazole was the only SGA associated with both statistically significant lower risk and mean change in QT Bc, with sertindole giving a statistically significant worsening effect on mean QT Bc. Other analyses did not demonstrate any statistically significant pooled effects for the studied SGAs, neither on the magnitude over mean or mean change, nor the risk on QT Bc prolongation. © 2011 The Author(s). | en_HK |
dc.language | eng | en_US |
dc.publisher | Sage Publications Ltd.. The Journal's web site is located at http://jop.sagepub.com | en_HK |
dc.relation.ispartof | Journal of Psychopharmacology | en_HK |
dc.rights | Journal of Psychopharmacology. Copyright © Sage Publications Ltd.. | - |
dc.subject | Bazett's correction | en_HK |
dc.subject | meta-analysis | en_HK |
dc.subject | QT interval | en_HK |
dc.subject | Second-generation antipsychotics | en_HK |
dc.subject.mesh | Antipsychotic Agents - adverse effects - pharmacology - therapeutic use | - |
dc.subject.mesh | Databases, Factual | - |
dc.subject.mesh | Long QT Syndrome - chemically induced | - |
dc.subject.mesh | Risk | - |
dc.subject.mesh | Schizophrenia - drug therapy | - |
dc.title | Effects on prolongation of Bazett's corrected QT interval of seven second-generation antipsychotics in the treatment of schizophrenia: A meta-analysis | en_HK |
dc.type | Article | en_HK |
dc.identifier.openurl | http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0269-8811&volume=25&issue=5&spage=646&epage=666&date=2011&atitle=Effects+on+prolongation+of+Bazett%27s+corrected+QT+interval+of+seven+second-generation+antipsychotics+in+the+treatment+of+schizophrenia:+a+meta-analysis | - |
dc.identifier.email | Chua, SE: sechua@hku.hk | en_HK |
dc.identifier.authority | Chua, SE=rp00438 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1177/0269881110376685 | en_HK |
dc.identifier.pmid | 20826552 | en_HK |
dc.identifier.scopus | eid_2-s2.0-79955445368 | en_HK |
dc.identifier.hkuros | 187406 | en_US |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-79955445368&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 25 | en_HK |
dc.identifier.issue | 5 | en_HK |
dc.identifier.spage | 646 | en_HK |
dc.identifier.epage | 666 | en_HK |
dc.identifier.eissn | 1461-7285 | - |
dc.identifier.isi | WOS:000289768000005 | - |
dc.publisher.place | United Kingdom | en_HK |
dc.identifier.scopusauthorid | Chung, AK=36871926600 | en_HK |
dc.identifier.scopusauthorid | Chua, SE=7201550427 | en_HK |
dc.identifier.issnl | 0269-8811 | - |