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Article: European bone mineral density loci are also associated with BMD in East-Asian populations

TitleEuropean bone mineral density loci are also associated with BMD in East-Asian populations
Authors
Styrkarsdottir, UHalldorsson, BVGudbjartsson, DFTang, NLSKoh, JMXiao, SMKwok, TCYKim, GSChan, JCNCherny, SLee, SHKwok, AHo, SGretarsdottir, SKostic, JPPalsson, STSigurdsson, GSham, PCKim, BJKung, AWCKim, SYWoo, JLeung, PCKong, AThorsteinsdottir, UStefansson, K
Issue Date2010
PublisherPublic Library of Science. The Journal's web site is located at http://www.plosone.org/home.action
Citation
Plos One, 2010, v. 5 n. 10 How to Cite?
DOI: http://dx.doi.org/10.1371/journal.pone.0013217
AbstractMost genome-wide association (GWA) studies have focused on populations of European ancestry with limited assessment of the influence of the sequence variants on populations of other ethnicities. To determine whether markers that we have recently shown to associate with Bone Mineral Density (BMD) in Europeans also associate with BMD in East-Asians we analysed 50 markers from 23 genomic loci in samples from Korea (n = 1,397) and two Chinese Hong Kong sample sets (n = 3,869 and n = 785). Through this effort we identified fourteen loci that associated with BMD in East-Asian samples using a false discovery rate (FDR) of 0.05; 1p36 (ZBTB40, P = 4.3×10 -9), 1p31 (GPR177, P = 0.00012), 3p22 (CTNNB1, P = 0.00013), 4q22 (MEPE, P = 0.0026), 5q14 (MEF2C, P = 1.3×10 -5), 6q25 (ESR1, P = 0.0011), 7p14 (STARD3NL, P = 0.00025), 7q21 (FLJ42280, P = 0.00017), 8q24 (TNFRSF11B, P = 3.4×10 -5), 11p15 (SOX6, P = 0.00033), 11q13 (LRP5, P = 0.0033), 13q14 (TNFSF11, P = 7.5×10 -5), 16q24 (FOXL1, P = 0.0010) and 17q21 (SOST, P = 0.015). Our study marks an early effort towards the challenge of cataloguing bone density variants shared by many ethnicities by testing BMD variants that have been established in Europeans, in East-Asians. © 2010 Styrkarsdottir et al.
Persistent Identifierhttp://hdl.handle.net/10722/135438
ISSN
1932-6203
2023 Impact Factor: 2.9
2023 SCImago Journal Rankings: 0.839
PubMed Central ID
PMC2951352
ISI Accession Number ID
WOS:000282633700012
Funding AgencyGrant Number
European CommunityFP7/2007-2013
HEALTH-F2-2008-201865-GEFOS
Korea Healthcare Technology
Ministry for Health, Welfare & Family Affairs, Republic of KoreaA010252
Research Grants Council of Hong KongCUHK 4101/02M
Chinese University of Hong Kong
Centre for Nutritional Studies
School of Public Health and Primary Care
Hong Kong Jockey Club Charities Foundation
Hong Kong Research Grant Council
HKU Foundation
University of Hong Kong
deCODE Genetics
Funding Information:

This work was supported by deCODE Genetics and funded in part by the European Community's Seventh Framework Programme (FP7/2007-2013)/grant agreement HEALTH-F2-2008-201865-GEFOS. The Korean study was supported by a grant from the Korea Healthcare Technology R& D Project, Ministry for Health, Welfare & Family Affairs, Republic of Korea (Project No.: A010252). The Chinese Hong Kong-I study was supported in part by grants from Research Grants Council of Hong Kong, (CUHK 4101/02M), Direct Grant from the Chinese University of Hong Kong, the Centre for Nutritional Studies, School of Public Health and Primary Care, and the Hong Kong Jockey Club Charities Foundation. The Hong Kong-II study was supported by Hong Kong Research Grant Council; The Bone Health fund of HKU Foundation; Matching Grant, CRCG Grant and The Osteoporosis Research Fund of The University of Hong Kong. The study design, data generation (in part), overall analysis of data, decision to publish and preparation of the manuscript was lead by employees of deCODE Genetics, a funder of this study.

References
References in Scopus

 

DC FieldValueLanguage
dc.contributor.authorStyrkarsdottir, Uen_HK
dc.contributor.authorHalldorsson, BVen_HK
dc.contributor.authorGudbjartsson, DFen_HK
dc.contributor.authorTang, NLSen_HK
dc.contributor.authorKoh, JMen_HK
dc.contributor.authorXiao, SMen_HK
dc.contributor.authorKwok, TCYen_HK
dc.contributor.authorKim, GSen_HK
dc.contributor.authorChan, JCNen_HK
dc.contributor.authorCherny, Sen_HK
dc.contributor.authorLee, SHen_HK
dc.contributor.authorKwok, Aen_HK
dc.contributor.authorHo, Sen_HK
dc.contributor.authorGretarsdottir, Sen_HK
dc.contributor.authorKostic, JPen_HK
dc.contributor.authorPalsson, STen_HK
dc.contributor.authorSigurdsson, Gen_HK
dc.contributor.authorSham, PCen_HK
dc.contributor.authorKim, BJen_HK
dc.contributor.authorKung, AWCen_HK
dc.contributor.authorKim, SYen_HK
dc.contributor.authorWoo, Jen_HK
dc.contributor.authorLeung, PCen_HK
dc.contributor.authorKong, Aen_HK
dc.contributor.authorThorsteinsdottir, Uen_HK
dc.contributor.authorStefansson, Ken_HK
dc.date.accessioned2011-07-27T01:35:09Z-
dc.date.available2011-07-27T01:35:09Z-
dc.date.issued2010en_HK
dc.identifier.citationPlos One, 2010, v. 5 n. 10en_HK
dc.identifier.issn1932-6203en_HK
dc.identifier.urihttp://hdl.handle.net/10722/135438-
dc.description.abstractMost genome-wide association (GWA) studies have focused on populations of European ancestry with limited assessment of the influence of the sequence variants on populations of other ethnicities. To determine whether markers that we have recently shown to associate with Bone Mineral Density (BMD) in Europeans also associate with BMD in East-Asians we analysed 50 markers from 23 genomic loci in samples from Korea (n = 1,397) and two Chinese Hong Kong sample sets (n = 3,869 and n = 785). Through this effort we identified fourteen loci that associated with BMD in East-Asian samples using a false discovery rate (FDR) of 0.05; 1p36 (ZBTB40, P = 4.3×10 -9), 1p31 (GPR177, P = 0.00012), 3p22 (CTNNB1, P = 0.00013), 4q22 (MEPE, P = 0.0026), 5q14 (MEF2C, P = 1.3×10 -5), 6q25 (ESR1, P = 0.0011), 7p14 (STARD3NL, P = 0.00025), 7q21 (FLJ42280, P = 0.00017), 8q24 (TNFRSF11B, P = 3.4×10 -5), 11p15 (SOX6, P = 0.00033), 11q13 (LRP5, P = 0.0033), 13q14 (TNFSF11, P = 7.5×10 -5), 16q24 (FOXL1, P = 0.0010) and 17q21 (SOST, P = 0.015). Our study marks an early effort towards the challenge of cataloguing bone density variants shared by many ethnicities by testing BMD variants that have been established in Europeans, in East-Asians. © 2010 Styrkarsdottir et al.en_HK
dc.languageengen_US
dc.publisherPublic Library of Science. The Journal's web site is located at http://www.plosone.org/home.actionen_HK
dc.relation.ispartofPLoS ONEen_HK
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subject.meshAsian Continental Ancestry Group - genetics-
dc.subject.meshBone Density - genetics-
dc.subject.meshEuropean Continental Ancestry Group - genetics-
dc.subject.meshGenome-Wide Association Study-
dc.subject.meshPolymorphism, Single Nucleotide-
dc.titleEuropean bone mineral density loci are also associated with BMD in East-Asian populationsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1932-6203&volume=5&issue=10&spage=e13217&epage=&date=2010&atitle=European+bone+mineral+density+loci+are+also+associated+with+BMD+in+East-Asian+populations-
dc.identifier.emailCherny, S: cherny@hku.hken_HK
dc.identifier.emailSham, PC: pcsham@hku.hken_HK
dc.identifier.emailKung, AWC: awckung@hku.hken_HK
dc.identifier.authorityCherny, S=rp00232en_HK
dc.identifier.authoritySham, PC=rp00459en_HK
dc.identifier.authorityKung, AWC=rp00368en_HK
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1371/journal.pone.0013217en_HK
dc.identifier.pmid20949110-
dc.identifier.pmcidPMC2951352-
dc.identifier.scopuseid_2-s2.0-78049233765en_HK
dc.identifier.hkuros188279en_US
dc.identifier.hkuros187294-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-78049233765&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume5en_HK
dc.identifier.issue10en_HK
dc.identifier.spagee13217en_US
dc.identifier.epagee13217en_US
dc.identifier.isiWOS:000282633700012-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridStyrkarsdottir, U=12761328700en_HK
dc.identifier.scopusauthoridHalldorsson, BV=6603240812en_HK
dc.identifier.scopusauthoridGudbjartsson, DF=6602358994en_HK
dc.identifier.scopusauthoridTang, NLS=7202344588en_HK
dc.identifier.scopusauthoridKoh, JM=7201756992en_HK
dc.identifier.scopusauthoridXiao, SM=7402022586en_HK
dc.identifier.scopusauthoridKwok, TCY=7006475934en_HK
dc.identifier.scopusauthoridKim, GS=14025693100en_HK
dc.identifier.scopusauthoridChan, JCN=7403287000en_HK
dc.identifier.scopusauthoridCherny, S=7004670001en_HK
dc.identifier.scopusauthoridLee, SH=36036801100en_HK
dc.identifier.scopusauthoridKwok, A=23985168800en_HK
dc.identifier.scopusauthoridHo, S=7403716908en_HK
dc.identifier.scopusauthoridGretarsdottir, S=6602887568en_HK
dc.identifier.scopusauthoridKostic, JP=6603314722en_HK
dc.identifier.scopusauthoridPalsson, ST=7004424939en_HK
dc.identifier.scopusauthoridSigurdsson, G=7005332253en_HK
dc.identifier.scopusauthoridSham, PC=34573429300en_HK
dc.identifier.scopusauthoridKim, BJ=7501563273en_HK
dc.identifier.scopusauthoridKung, AWC=7102322339en_HK
dc.identifier.scopusauthoridKim, SY=26663842900en_HK
dc.identifier.scopusauthoridWoo, J=36040369400en_HK
dc.identifier.scopusauthoridLeung, PC=7401747829en_HK
dc.identifier.scopusauthoridKong, A=34667880600en_HK
dc.identifier.scopusauthoridThorsteinsdottir, U=6602988969en_HK
dc.identifier.scopusauthoridStefansson, K=7005997553en_HK
dc.identifier.issnl1932-6203-

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