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- Publisher Website: 10.1002/ijc.25857
- Scopus: eid_2-s2.0-80052036411
- PMID: 21165951
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Article: Induction of mutant p53-dependent apoptosis in human hepatocellular carcinoma by targeting stress protein mortalin
Title | Induction of mutant p53-dependent apoptosis in human hepatocellular carcinoma by targeting stress protein mortalin | ||||||
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Authors | |||||||
Keywords | human hepatocellular carcinoma mortalin mutant p53-dependent apoptosis RNAi therapy | ||||||
Issue Date | 2011 | ||||||
Publisher | John Wiley & Sons, Inc.. The Journal's web site is located at http://www3.interscience.wiley.com/journal/29331/home | ||||||
Citation | International Journal Of Cancer, 2011, v. 129 n. 8, p. 1806-1814 How to Cite? | ||||||
Abstract | Stress protein mortalin (mtHSP70) is highly expressed in cancer cells. It was shown to contribute to carcinogenesis by sequestrating the wild type p53, a key tumor suppressor protein, in the cytoplasm resulting in an abrogation of its transcriptional activation function. We have found that the level of mortalin expression has significant correlation with human hepatocellular carcinoma (HCC) malignancy and therefore investigated whether it interacts with and influences the activities of mutant p53, frequently associated with HCC development. We have detected mortalin-p53 interactions in liver tumor and five HCC cell lines that harbored mutant p53. The data was in contrast to the normal liver and immortalized normal hepatocytes that lacked mortalin-p53 interaction. Furthermore, we have found that the shRNA-mediated mortalin silencing could induce mutant p53-mediated tumor-specific apoptosis in HCC. Such allotment of apoptotic function to mutant p53 by targeting mortalin-p53 interaction in cancer cells is a promising strategy for HCC therapy. Copyright © 2010 UICC. | ||||||
Persistent Identifier | http://hdl.handle.net/10722/135551 | ||||||
ISSN | 2023 Impact Factor: 5.7 2023 SCImago Journal Rankings: 2.131 | ||||||
ISI Accession Number ID |
Funding Information: Grant sponsors: The HKU CRCG seed fund, New Energy & Industrial Technology Development Organization (NEDO) and Grant-in-Aid for Japan Society for the Promotion of Science (JSPS), Japan | ||||||
References |
DC Field | Value | Language |
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dc.contributor.author | Lu, WJ | en_HK |
dc.contributor.author | Lee, NP | en_HK |
dc.contributor.author | Kaul, SC | en_HK |
dc.contributor.author | Lan, F | en_HK |
dc.contributor.author | Poon, RTP | en_HK |
dc.contributor.author | Wadhwa, R | en_HK |
dc.contributor.author | Luk, JM | en_HK |
dc.date.accessioned | 2011-07-27T01:37:01Z | - |
dc.date.available | 2011-07-27T01:37:01Z | - |
dc.date.issued | 2011 | en_HK |
dc.identifier.citation | International Journal Of Cancer, 2011, v. 129 n. 8, p. 1806-1814 | en_HK |
dc.identifier.issn | 0020-7136 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/135551 | - |
dc.description.abstract | Stress protein mortalin (mtHSP70) is highly expressed in cancer cells. It was shown to contribute to carcinogenesis by sequestrating the wild type p53, a key tumor suppressor protein, in the cytoplasm resulting in an abrogation of its transcriptional activation function. We have found that the level of mortalin expression has significant correlation with human hepatocellular carcinoma (HCC) malignancy and therefore investigated whether it interacts with and influences the activities of mutant p53, frequently associated with HCC development. We have detected mortalin-p53 interactions in liver tumor and five HCC cell lines that harbored mutant p53. The data was in contrast to the normal liver and immortalized normal hepatocytes that lacked mortalin-p53 interaction. Furthermore, we have found that the shRNA-mediated mortalin silencing could induce mutant p53-mediated tumor-specific apoptosis in HCC. Such allotment of apoptotic function to mutant p53 by targeting mortalin-p53 interaction in cancer cells is a promising strategy for HCC therapy. Copyright © 2010 UICC. | en_HK |
dc.language | eng | en_US |
dc.publisher | John Wiley & Sons, Inc.. The Journal's web site is located at http://www3.interscience.wiley.com/journal/29331/home | en_HK |
dc.relation.ispartof | International Journal of Cancer | en_HK |
dc.rights | International Journal of Cancer. Copyright © John Wiley & Sons, Inc.. | - |
dc.subject | human hepatocellular carcinoma | en_HK |
dc.subject | mortalin | en_HK |
dc.subject | mutant p53-dependent apoptosis | en_HK |
dc.subject | RNAi | en_HK |
dc.subject | therapy | en_HK |
dc.title | Induction of mutant p53-dependent apoptosis in human hepatocellular carcinoma by targeting stress protein mortalin | en_HK |
dc.type | Article | en_HK |
dc.identifier.openurl | http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0020-7136&volume=129&issue=8&spage=1806&epage=1814&date=2010&atitle=Induction+of+mutant+p53-dependent+apoptosis+in+human+hepatocellular+carcinoma+by+targeting+stress+protein+mortalin | - |
dc.identifier.email | Lee, NP: nikkilee@hku.hk | en_HK |
dc.identifier.email | Poon, RTP: poontp@hkucc.hku.hk | en_HK |
dc.identifier.email | Luk, JM: jmluk@hkucc.hku.hk | en_HK |
dc.identifier.authority | Lee, NP=rp00263 | en_HK |
dc.identifier.authority | Poon, RTP=rp00446 | en_HK |
dc.identifier.authority | Luk, JM=rp00349 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1002/ijc.25857 | en_HK |
dc.identifier.pmid | 21165951 | - |
dc.identifier.scopus | eid_2-s2.0-80052036411 | en_HK |
dc.identifier.hkuros | 188089 | en_US |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-80052036411&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 129 | en_HK |
dc.identifier.issue | 8 | en_HK |
dc.identifier.spage | 1806 | en_HK |
dc.identifier.epage | 1814 | en_HK |
dc.identifier.isi | WOS:000294224300002 | - |
dc.publisher.place | United States | en_HK |
dc.identifier.scopusauthorid | Lu, WJ=35187521100 | en_HK |
dc.identifier.scopusauthorid | Lee, NP=7402722690 | en_HK |
dc.identifier.scopusauthorid | Kaul, SC=7403092602 | en_HK |
dc.identifier.scopusauthorid | Lan, F=36349345200 | en_HK |
dc.identifier.scopusauthorid | Poon, RTP=7103097223 | en_HK |
dc.identifier.scopusauthorid | Wadhwa, R=7006876025 | en_HK |
dc.identifier.scopusauthorid | Luk, JM=7006777791 | en_HK |
dc.identifier.issnl | 0020-7136 | - |