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Conference Paper: Aldose reductase deficiency reduces retinal injury in the mouse oxygen-induced retinopathy model

TitleAldose reductase deficiency reduces retinal injury in the mouse oxygen-induced retinopathy model
Authors
Lo, ACFu, ZLi, SYWong, DChung, SK
Keywords697 retinal neovascularization
696 retinal glia
612 neuroprotection
Issue Date2011
Citation
The 2011 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO), Font Lauderdale, FL., 1-5 May 2011. How to Cite?
AbstractPURPOSE: Retinopathy of prematurity (ROP) is a common retinal disease in preterm infants, causing childhood blindness. The lack of pharmacological treatment for ROP creates a great need for effective and safe therapies in the fragile developing preterm infants. ROP is thought to be associated with oxidative stress due to the immature antioxidant system in preterm infants. We previously showed that genetic deletion or pharmacological inhibition of aldose reductase (AR), a rate limiting enzyme in the polyol pathway, prevented retinal ganglion cell loss and oxidative stress after retinal ischemia/reperfusion injury. Here, we assessed the effects of AR deletion on retinal injury induced by oxygen-induced retinopathy (OIR), a mouse model of ROP. METHODS: Seven-day-old pups were …
DescriptionSession 411. Angiogenesis 1: no. 3985/A52
Persistent Identifierhttp://hdl.handle.net/10722/136445

 

DC FieldValueLanguage
dc.contributor.authorLo, ACen_US
dc.contributor.authorFu, Zen_US
dc.contributor.authorLi, SYen_US
dc.contributor.authorWong, Den_US
dc.contributor.authorChung, SKen_US
dc.date.accessioned2011-07-27T02:16:15Z-
dc.date.available2011-07-27T02:16:15Z-
dc.date.issued2011en_US
dc.identifier.citationThe 2011 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO), Font Lauderdale, FL., 1-5 May 2011.en_US
dc.identifier.urihttp://hdl.handle.net/10722/136445-
dc.descriptionSession 411. Angiogenesis 1: no. 3985/A52-
dc.description.abstractPURPOSE: Retinopathy of prematurity (ROP) is a common retinal disease in preterm infants, causing childhood blindness. The lack of pharmacological treatment for ROP creates a great need for effective and safe therapies in the fragile developing preterm infants. ROP is thought to be associated with oxidative stress due to the immature antioxidant system in preterm infants. We previously showed that genetic deletion or pharmacological inhibition of aldose reductase (AR), a rate limiting enzyme in the polyol pathway, prevented retinal ganglion cell loss and oxidative stress after retinal ischemia/reperfusion injury. Here, we assessed the effects of AR deletion on retinal injury induced by oxygen-induced retinopathy (OIR), a mouse model of ROP. METHODS: Seven-day-old pups were …-
dc.languageengen_US
dc.relation.ispartofAnnual Meeting of the Association for Research in Vision & Ophthalmology, ARVO 2011en_US
dc.subject697 retinal neovascularization-
dc.subject696 retinal glia-
dc.subject612 neuroprotection-
dc.titleAldose reductase deficiency reduces retinal injury in the mouse oxygen-induced retinopathy modelen_US
dc.typeConference_Paperen_US
dc.identifier.emailLo, AC: amylo@hkucc.hku.hken_US
dc.identifier.emailWong, D: shdwong@hku.hken_US
dc.identifier.emailChung, SK: skchung@hkucc.hku.hken_US
dc.identifier.authorityLo, AC=rp00425en_US
dc.identifier.authorityWong, D=rp00516en_US
dc.identifier.authorityChung, SK=rp00381en_US
dc.description.naturelink_to_OA_fulltext-
dc.identifier.hkuros186643en_US

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