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- Publisher Website: 10.1007/s10238-010-0105-6
- Scopus: eid_2-s2.0-79951949990
- PMID: 20661620
- WOS: WOS:000286982400004
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Article: Effect of allogeneic bone marrow-derived mesenchymal stem cells transplantation in a polyI:C-induced primary biliary cirrhosis mouse model
Title | Effect of allogeneic bone marrow-derived mesenchymal stem cells transplantation in a polyI:C-induced primary biliary cirrhosis mouse model | ||||
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Authors | |||||
Keywords | Bone marrow Cytokine MSC PBC Regulatory T cells | ||||
Issue Date | 2011 | ||||
Publisher | Springer-Verlag Italia Srl. The Journal's web site is located at http://www.springer.it/libri_libro.asp?id=238 | ||||
Citation | Clinical And Experimental Medicine, 2011, v. 11 n. 1, p. 25-32 How to Cite? | ||||
Abstract | Primary biliary cirrhosis (PBC) is a slowly progressive autoimmune disease of unknown mechanism. We established a PBC animal model by injecting C57BL/6 mice with polyinosinic-polycytidylic acid sodium (polyI:C) to investigate the therapeutic effect of bone marrow-derived mesenchymal stem cells (BM-MSC) on this model. After 6 weeks of MSC infusion, serum aminotransferase and autoimmune antibodies declined, and histological examination by hematoxylin and eosin staining showed significant amelioration of monocytes infiltration around bile ducts of mice treated with BM-MSC. Interestingly, allogeneic BM-MSC transplantation markedly increased CD4+Foxp3+ regulatory T cells in peripheral blood as well as in lymph nodes when analyzed by flow cytometry. Further examination showed serum TGF-β1 increased but IFN-γ decreased significantly in PBC mice treated with MSC, while with no obvious change in IL-10 expression. Our results for the first time suggested that BM-MSC transplantation could regulate systemic immune response and enhance recovery in liver inflammation of PBC mice, raising the possibility for clinical application of allogeneic MSC in treatment of early-stage PBC patients. © 2010 Springer-Verlag. | ||||
Persistent Identifier | http://hdl.handle.net/10722/137631 | ||||
ISSN | 2023 Impact Factor: 3.2 2023 SCImago Journal Rankings: 1.038 | ||||
ISI Accession Number ID |
Funding Information: This work was supported by a grant from the Jiangsu Province 135 Talent Foundation (RC2007004). | ||||
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Wang, D | en_HK |
dc.contributor.author | Zhang, H | en_HK |
dc.contributor.author | Liang, J | en_HK |
dc.contributor.author | Gu, Z | en_HK |
dc.contributor.author | Ma, X | en_HK |
dc.contributor.author | Huang, J | en_HK |
dc.contributor.author | Lin, J | en_HK |
dc.contributor.author | Hou, Y | en_HK |
dc.contributor.author | Lu, L | en_HK |
dc.contributor.author | Sun, L | en_HK |
dc.date.accessioned | 2011-08-26T14:29:47Z | - |
dc.date.available | 2011-08-26T14:29:47Z | - |
dc.date.issued | 2011 | en_HK |
dc.identifier.citation | Clinical And Experimental Medicine, 2011, v. 11 n. 1, p. 25-32 | en_HK |
dc.identifier.issn | 1591-8890 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/137631 | - |
dc.description.abstract | Primary biliary cirrhosis (PBC) is a slowly progressive autoimmune disease of unknown mechanism. We established a PBC animal model by injecting C57BL/6 mice with polyinosinic-polycytidylic acid sodium (polyI:C) to investigate the therapeutic effect of bone marrow-derived mesenchymal stem cells (BM-MSC) on this model. After 6 weeks of MSC infusion, serum aminotransferase and autoimmune antibodies declined, and histological examination by hematoxylin and eosin staining showed significant amelioration of monocytes infiltration around bile ducts of mice treated with BM-MSC. Interestingly, allogeneic BM-MSC transplantation markedly increased CD4+Foxp3+ regulatory T cells in peripheral blood as well as in lymph nodes when analyzed by flow cytometry. Further examination showed serum TGF-β1 increased but IFN-γ decreased significantly in PBC mice treated with MSC, while with no obvious change in IL-10 expression. Our results for the first time suggested that BM-MSC transplantation could regulate systemic immune response and enhance recovery in liver inflammation of PBC mice, raising the possibility for clinical application of allogeneic MSC in treatment of early-stage PBC patients. © 2010 Springer-Verlag. | en_HK |
dc.language | eng | en_US |
dc.publisher | Springer-Verlag Italia Srl. The Journal's web site is located at http://www.springer.it/libri_libro.asp?id=238 | en_HK |
dc.relation.ispartof | Clinical and Experimental Medicine | en_HK |
dc.subject | Bone marrow | - |
dc.subject | Cytokine | - |
dc.subject | MSC | - |
dc.subject | PBC | - |
dc.subject | Regulatory T cells | - |
dc.subject.mesh | Animals | en_HK |
dc.subject.mesh | Antigens, CD4 - analysis | en_HK |
dc.subject.mesh | Autoantibodies - blood | en_HK |
dc.subject.mesh | Female | en_HK |
dc.subject.mesh | Flow Cytometry | en_HK |
dc.subject.mesh | Forkhead Transcription Factors - analysis | en_HK |
dc.subject.mesh | Histocytochemistry | en_HK |
dc.subject.mesh | Interleukin-10 - biosynthesis | en_HK |
dc.subject.mesh | Liver - pathology | en_HK |
dc.subject.mesh | Liver Cirrhosis, Biliary - chemically induced - therapy | en_HK |
dc.subject.mesh | Male | en_HK |
dc.subject.mesh | Mesenchymal Stem Cell Transplantation | en_HK |
dc.subject.mesh | Mice | en_HK |
dc.subject.mesh | Mice, Inbred C57BL | en_HK |
dc.subject.mesh | Poly I-C - toxicity | en_HK |
dc.subject.mesh | T-Lymphocytes, Regulatory - chemistry - immunology | en_HK |
dc.subject.mesh | Transaminases - blood | en_HK |
dc.subject.mesh | Transplantation, Homologous | en_HK |
dc.title | Effect of allogeneic bone marrow-derived mesenchymal stem cells transplantation in a polyI:C-induced primary biliary cirrhosis mouse model | en_HK |
dc.type | Article | en_HK |
dc.identifier.email | Lu, L:liweilu@hkucc.hku.hk | en_HK |
dc.identifier.authority | Lu, L=rp00477 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1007/s10238-010-0105-6 | en_HK |
dc.identifier.pmid | 20661620 | - |
dc.identifier.scopus | eid_2-s2.0-79951949990 | en_HK |
dc.identifier.hkuros | 191303 | en_US |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-79951949990&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 11 | en_HK |
dc.identifier.issue | 1 | en_HK |
dc.identifier.spage | 25 | en_HK |
dc.identifier.epage | 32 | en_HK |
dc.identifier.isi | WOS:000286982400004 | - |
dc.publisher.place | Italy | en_HK |
dc.identifier.citeulike | 7774631 | - |
dc.identifier.issnl | 1591-8890 | - |